Document Detail

Latent development of occlusive coronary atherosclerosis as a cause of decompensation of non-ischemic dilated cardiomyopathy.
MedLine Citation:
PMID:  18580063     Owner:  NLM     Status:  MEDLINE    
Four patients with chronically well-compensated, non-ischemic dilated cardiomyopathy (NIDC) presented with occlusive atherosclerotic coronary artery disease as the cause of subacute decompensation (FC III-IV heart failure) 8-13 years following the diagnosis of NIDC. In addition to the atherogenic condition of heart failure, 3 of the patients acquired major atherosclerotic risk factors (dyslipidemia, diabetes mellitus) during the interval between the diagnoses of NIDC and problematic atherosclerotic coronary disease. For each patient, dyspnea on exertion was the primary symptom during the subacute decompensation. Only 1 patient noted precordial chest pain in the form of atypical angina during some of the dyspneic events. The diagnosis of occlusive coronary artery disease was made by coronary angiography, followed by angioplasty-stent deployment in 3 patients and coronary artery bypass surgery in 1; all improved to their baseline FC I-II status following these coronary interventions. As survival of patients with NIDC increases, occlusive coronary artery disease may enter an otherwise stable clinical course to provoke unanticipated decompensation (principally dyspnea), and can do so without causing angina pectoris as a heralding symptom.
Bryan M White; Rohit Mehta; Philip F Binkley; Carl V Leier
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Publication Detail:
Type:  Journal Article     Date:  2008-06-26
Journal Detail:
Title:  Cardiology     Volume:  112     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2009  
Date Detail:
Created Date:  2008-12-02     Completed Date:  2009-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Division of Cardiovascular Medicine, Ohio State University College of Medicine and Public Health, Columbus, Ohio, USA.
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MeSH Terms
Angina Pectoris / epidemiology,  etiology*
Cardiomyopathy, Dilated / epidemiology,  etiology*
Coronary Artery Disease / complications*,  epidemiology
Disease Progression
Heart Failure / epidemiology,  etiology*
Middle Aged
Risk Factors

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