| Latent class analysis of functional somatic symptoms in a population-based sample of twins. | |
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MedLine Citation:
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PMID: 20403503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study aimed to investigate empirically how and in what way individuals with symptoms of functional somatic syndromes should be classified. We also aimed to look into genetic and environmental influences on the classification. METHOD: A total of 28,531 twins aged 41-64 underwent screening interviews via a computer-assisted data collection system from 1998 to 2002. Nine functional somatic symptoms (abnormal tiredness, general muscular pain, recurrent abdominal discomfort, back pain, gastroesophageal reflux, recurrent headache, recurrent urinary problem, dizziness, breathlessness at rest) were assessed using structured questions in a blinded manner. Latent class analysis was applied to the data. Structural equation modeling was further performed in order to estimate the relative importance of genetic and environmental influences on class probability. RESULTS: Latent class analysis resulted in a five-class solution. Individuals in the first class did not show any health problems. Those assigned to the second, third, and fourth classes tended to have abnormal tiredness, gastrointestinal problems, and pain-related symptoms, respectively. Individuals in the fifth class had multiple symptoms to a greater extent than the other classes. All the five classes showed modest genetic influences (7-29% of the total variation) with gender differences except Class 3; however, the majority of influences on the class membership derived from unique environmental effects. CONCLUSION: The findings suggested the necessity of redefining the existing classification criteria for functional somatic syndromes in terms of single (uncomplicated) or multiple (complicated) syndromes. Environmental influences are important for the etiology of functional somatic syndromes. |
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Authors:
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Kenji Kato; Patrick F Sullivan; Nancy L Pedersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study Date: 2010-03-01 |
Journal Detail:
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Title: Journal of psychosomatic research Volume: 68 ISSN: 1879-1360 ISO Abbreviation: J Psychosom Res Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-07-21 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0376333 Medline TA: J Psychosom Res Country: England |
Other Details:
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Languages: eng Pagination: 447-53 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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School of Nursing and Rehabilitation, International University of Health and Welfare, Odawara, Japan. kenji-kato@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anxiety / epidemiology Chronic Disease Comorbidity Depression / epidemiology Diseases in Twins* Fatigue Syndrome, Chronic / classification*, epidemiology Female Humans Irritable Bowel Syndrome / classification*, epidemiology Male Middle Aged Pain / classification*, epidemiology Patient Selection Prevalence Psychiatric Status Rating Scales Psychophysiologic Disorders / classification*, epidemiology* Questionnaires Somatoform Disorders / classification*, epidemiology Sweden |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI056014-01A1/AI/NIAID NIH HHS; R01 CA085739-01A1/CA/NCI NIH HHS; R01 NS041483-01/NS/NINDS NIH HHS |
| Comments/Corrections | |
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