| Latent cerebral hypoperfusion in a boy with persistent nephrotic syndrome. | |
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MedLine Citation:
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PMID: 12453603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pediatricians are often faced with both bad temper and decreased daily activity in children with persistent nephrotic syndrome. These problems, which might affect both mental and physical development, have been explained as a consequence of general fatigue due to systemic edema and/or long-term hospitalization. However, other factors, such as cerebral hypoperfusion, may be involved. We experienced a case of a boy with steroid-resistant nephrotic syndrome who showed diffuse cerebral hypoperfusion on single photon emission computed tomography. Diffuse cerebral hypoperfusion dramatically resolved as the nephrotic syndrome remitted. His bad temper, decreased daily activity, and delay of speech and motor development also improved. In our patient, cerebral hypoperfusion might have been associated with his mental problems, physical problems, and delayed development of speech. |
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Authors:
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Shu-ichi Ito; Atsuo Nezu; Tomoko Nakamura; Masami Kawamoto; Yukoh Aihara; Shumpei Yokota |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Brain & development Volume: 24 ISSN: 0387-7604 ISO Abbreviation: Brain Dev. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-27 Completed Date: 2003-02-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7909235 Medline TA: Brain Dev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 780-3 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science B.V. |
Affiliation:
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Department of Pediatrics, Yokohama City University Medical Center, 4-57, Urafune-cho, Minami-ku, 232-0024 Yokohama, Japan. sk-ito@tb3.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Cortex
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pathology,
physiopathology,
radionuclide imaging Cerebrovascular Circulation / physiology Child, Preschool Chronic Disease Cyclosporine / therapeutic use Developmental Disabilities / diagnosis, etiology*, physiopathology* Electroencephalography Humans Hypoxia-Ischemia, Brain / diagnosis, etiology*, physiopathology Magnetic Resonance Imaging Male Mood Disorders / etiology Nephrotic Syndrome / complications*, drug therapy, physiopathology Prednisolone / analogs & derivatives*, therapeutic use Recovery of Function / drug effects, physiology Tomography, Emission-Computed, Single-Photon Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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50-24-8/Prednisolone; 57072-99-8/methyl prednisolonate; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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