| Latent Tuberculosis in Rheumatoid Arthritis: Evaluating Cellular Response and High-Resolution Computed Tomography. | |
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MedLine Citation:
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PMID: 22401741 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: The diagnosis of latent tuberculosis (LTB) in patients with rheumatoid arthritis (RA) has become important with the introduction of anti-tumor necrosis factor (anti-TNF-α) agents and the appearance of active tuberculosis cases in these patients. The tuberculin skin test (TST) has limited value in patients with RA. Tests based on the release of interferon-gamma (IFN-γ) are being studied, but their role has not been well established for this group of patients. OBJECTIVES: To compare the diagnosis of LTB in patients with RA by using cellular immune response to the TST and T.SPOT-TB. Additionally, findings of tomography studies compatible with LTB were used. METHODS: Clinical evaluation, TST, T.SPOT-TB and high-resolution computed tomography (HRCT) in a group of patients with RA at the University Hospital of the Federal University of Goiás. RESULTS: Response to the TST was lower in patients with RA (13.5%) compared to the predicted values of the general population. T.SPOT-TB identified a higher number of patients with LTB than the TST (36.8%). HRCT showed changes compatible with LTB in 52.9% of the patients, including 8 of the 11 patients with negative TST and T.SPOT-TB. CONCLUSIONS: The TST by itself is insufficient to diagnose LTB. A higher number of positive results were obtained with T.SPOT-TB when compared to the TST. Nevertheless, it was negative in a large percentage of patients with tomography findings consistent with LTB. HRCT is readily available in most large health-care centers and it could be incorporated into the diagnostic strategy for LTB in patients with RA. |
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Authors:
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Daniela G S Tannus Silva; Bruna Daniella Silva; Pedro Paulo Torres; Pedro José Santana Junior; Ana Paula Junqueira-Kipnis; Marcelo Fouad Rabahi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-6 |
Journal Detail:
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Title: Archivos de bronconeumologia Volume: - ISSN: 1579-2129 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0354720 Medline TA: Arch Bronconeumol Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 SEPAR. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, Brasil. |
Vernacular Title:
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Tuberculosis latente en la artritis reumatoide. Evaluación de la respuesta celular y tomografía computarizada de alta resolución. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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