| Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. | |
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MedLine Citation:
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PMID: 20638470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector potential. This study investigated whether effector-memory cells also account for the CD8TL egress from peripheral blood following exercise. As latent Cytomegalovirus (CMV) infection is associated with a robust expansion in the number and proportion of effector-memory CD8TLs, we also investigated if CMV serostatus was a determinant of the CD8TL responses to exercise. Fourteen males (Mean age 35, SD ± 14 yrs), half of whom were CMV seropositive (CMV(+)), ran on a treadmill for 60 min at 80% VO(2) max. Blood was collected at baseline, during the final minute of exercise, and 15 min and 60 min thereafter. CD8TL memory subsets were characterised by flow cytometry, using the cell-surface markers CD45RA, CD27, and CD28. The results confirmed that CD8TLs with an effector-memory phenotype (CD27(-)CD28(-)CD45RA(+/-)) exhibited the largest increase during exercise (+200% to +250%), and also showed the largest egress from blood 60 min post-exercise (down to 40% of baseline values). Strikingly, the mobilisation and subsequent egress of total CD8TLs was nearly twice as large in CMV(+) individuals. This effect appeared specific to CD8TLs, and was not seen for CD4(+) T lymphocytes or total lymphocytes. This effect of CMV serostatus was largely driven by the higher numbers of exercise-responsive effector-memory CD8TLs in the CMV(+) participants. This is the first study to demonstrate that infection history is a determinant of immune system responses to exercise. |
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Authors:
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James E Turner; Sarah Aldred; Oliver C Witard; Mark T Drayson; Paul M Moss; Jos A Bosch |
Publication Detail:
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Type: Journal Article Date: 2010-07-16 |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 24 ISSN: 1090-2139 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
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Languages: eng Pagination: 1362-70 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaerobic Threshold / physiology CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / physiology* Cytomegalovirus Infections / blood, immunology*, virology Exercise / physiology* Exercise Test Flow Cytometry Humans Immunologic Memory / immunology Immunologic Surveillance Lymphocyte Count Male Virus Latency |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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