Document Detail


Latency of the ventilatory chemoreflex response to hypoxia in humans.
MedLine Citation:
PMID:  8351446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Latencies for the ventilatory response to hypoxia have been estimated from data from experiments in which square waves of isocapnic hypoxia (periods 30 sec and 60 sec) were presented to 5 subjects. Distorted steps were excluded from the analysis, and the remaining steps were time-aligned relative to the step and then averaged. For the 30 sec data, the median latency for the response to the step into hypoxia was 1 breath or 5.1 sec (time to mid-point of first significantly different breath) and for the step out of hypoxia was 1 breath or 4.7 sec. The number of transients analyzed averaged 87 per subject per transition type. For the 60 sec data, the median latency for the step into hypoxia was 2 breaths or 6.8 sec, and for the step out of hypoxia was 2 breaths or 6.0 sec. The number of transients analyzed averaged 40 per subject per transition type. These latencies are generally shorter than those reported previously and suggest that the ventilatory variability may have served to lengthen the measured latency of response in previous studies.
Authors:
I D Clement; P A Robbins
Related Documents :
12706066 - Intermittent hypoxia and plasticity of respiratory chemoreflexes in metamorphic bullfro...
15837126 - Interaction between tissue oxygen tension and nadh imaging during synaptic stimulation ...
18057976 - Low intense physical exercise in normobaric hypoxia leads to more weight loss in obese ...
1491506 - Effects of acute hypoxia on ventilatory response at the onset of cycle exercise in man.
989476 - Bioavailability of tolamolol.
18403456 - Physical exercise improves plasmatic levels of il-10, left ventricular end-diastolic pr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  92     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-13     Completed Date:  1993-09-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  277-87     Citation Subset:  IM    
Affiliation:
University Laboratory of Physiology, Oxford, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anoxia / physiopathology*
Carbon Dioxide
Chemoreceptor Cells / physiopathology*
Female
Humans
Male
Oxygen
Partial Pressure
Reaction Time
Reflex / physiology*
Respiration*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dynamics of the ventilatory response to hypoxia in humans.
Next Document:  Ventilatory response to exercise after heart and lung denervation in humans.