| Late tissue reactions after single-fraction sequential half-body irradiation (HBI) in patients with non-Hodgkin's lymphomas. | |
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MedLine Citation:
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PMID: 2254118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lung and hepatic toxicities constituted the main radiation-related damage after half-body irradiation (HBI) used as the treatment for patients with non-Hodgkin's lymphomas (NHL). Liver damage was mostly transient after a single dose of 8 Gy and could be well monitored by serum enzyme levels. A dose-response relationship could be shown for lung damage in the single dose range of 6.25-9.25 Gy, but the relationship did not reach statistical significance. A significant dose-rate effect could be shown. Mediastinal involvement by lymphoma seemed to increase the risk of pneumonitis. In a radical setting half-body irradiation is recommended to be used at a low dose-rate or as a multifraction irradiation in order to reduce the risk of liver and lung toxicities. |
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Authors:
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H K Awwad; S el Badawy; K el Ghamrawy; M el Mongy; S Rizk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 19 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-01-18 Completed Date: 1991-01-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1229-32 Citation Subset: IM |
Affiliation:
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Radiotherapy Department, National Cancer Institute, Cairo, Egypt. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dose-Response Relationship, Radiation Female Humans Liver / radiation effects Lung / radiation effects Lymphoma, Non-Hodgkin / radiotherapy* Male Middle Aged Pneumonia / etiology Whole-Body Irradiation / adverse effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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