| Late temporal lobe necrosis in patients with nasopharyngeal carcinoma: evaluation with combined multi-section diffusion weighted and perfusion weighted MR imaging. | |
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MedLine Citation:
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PMID: 11566238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Late temporal lobe necrosis is a well-known and serious complication in patients with nasopharyngeal carcinoma (NPC) following radiotherapy. Owing to the close proximity to the skull base, the medial temporal lobes are inevitably included in the target volume of irradiation. Patients with NPC provide a unique opportunity in study of delay radiation effect in normal human brain. The objective of this study was to evaluate late temporal lobe radiation injury by combined multi-section diffusion weighted and perfusion weighted MR imaging. We prospectively studied 16 patients with typical clinical symptoms of late temporal lobe necrosis or other abnormalities in the temporal lobes incidentally detected by conventional MR imaging. All patients had a previous history of radiotherapy for histologically proven NPC. Conventional T1- and T2-weighted images, fast gradient echo with echo-planar diffusion-weighted and perfusion-weighted MR imaging were performed. Apparent diffusion coefficient (ADC) map and relative cerebral blood volume (rCBV) map were computed via commercially available software. MR diffusion and perfusion images were then analyzed and graded by two independent observers with focusing on the diffusion and perfusion mismatch. The temporal lobe lesions displayed marked high diffusion on the ADC map. The rCBV map also revealed marked hypoperfusion in these temporal lobe lesions in all patients. The areas of abnormality on the rCBV map were significantly larger than the lesions on the ADC map in 14 patients (observer 1) and 13 patients (observer 2). Since late temporal lobe necrosis is probably caused by damage of the endothelium of vessels and ischemia, perfusion and diffusion mismatch might imply injured tissue but potentially salvageable brain tissue. A mismatch may be potentially used to predict the response to treatment in-patients with late temporal lobe necrosis. |
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Authors:
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E Y Tsui; J H Chan; R G Ramsey; T W Leung; Y K Cheung; S H Luk; K F Lai; K P Wong; D Fong; M K Yuen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of radiology Volume: 39 ISSN: 0720-048X ISO Abbreviation: Eur J Radiol Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-21 Completed Date: 2001-10-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, Tuen Mun Hospital, Tuen Mun, NT, Hong Kong. eyktsui@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contrast Media Echo-Planar Imaging Female Gadolinium DTPA / diagnostic use Humans Magnetic Resonance Imaging / methods* Male Nasopharyngeal Neoplasms / radiotherapy* Necrosis Prospective Studies Radiation Injuries / diagnosis* Temporal Lobe / pathology*, radiation effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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