Document Detail

Late systolic wave on brachial artery blood flow velocity pattern in patients with coronary artery disease and its relation to vascular stiffness.
MedLine Citation:
PMID:  11512691     Owner:  NLM     Status:  MEDLINE    
Duplex-Doppler study typically exhibits triphasic brachial artery blood flow velocity pattern in subjects classified as normal without clinically evident atherosclerotic complications, heart disease, hypertension, or diabetes mellitus. In this study, the authors described the late systolic wave on the brachial artery blood flow velocity pattern in patients with coronary artery disease and investigated the relation between late systolic wave and vascular stiffness. Blood flow profile and velocity of the brachial artery were determined noninvasively by ultrasound pulsed-Doppler technique under the guidance of a B-mode ultrasound image in 96 patients with coronary artery disease (CAD). The control group consisted of 23 healthy subjects with no or maximally 2 risk factors (only among age, cigarette smoking, obesity, and gender) for vascular disease. None of the patients and controls had clinical evidence of arterial disorders at upper extremities. In 32 patients (33%) with CAD, a late systolic wave was observed in the brachial artery Doppler study. On the other hand, no late systolic wave was observed in the healthy subjects. In addition, multivessel disease, hypertension, advanced age, diabetes, and smoking were significantly more frequent in patients with the late systolic wave. In conclusion, peripheral arterial abnormalities induced by vascular stiffness may produce alterations in regional wave reflections, and the normal triphasic pattern of the brachial artery blood flow may change by the appearance of the late systolic wave.
N Güler; B Eryonucu; M Bilge; O Etlik; R Erkoç; M E Sakarya
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Angiology     Volume:  52     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-21     Completed Date:  2001-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  527-32     Citation Subset:  IM    
Department of Cardiology, School of Medicine, Yüzüncü Yil University, Van, Turkey.
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MeSH Terms
Analysis of Variance
Blood Flow Velocity
Brachial Artery / physiopathology,  ultrasonography*
Chi-Square Distribution
Coronary Disease / physiopathology*,  ultrasonography*
Coronary Vessels / physiopathology,  ultrasonography*
Middle Aged
Reference Values
Risk Assessment
Sensitivity and Specificity
Systole / physiology*
Ultrasonography, Doppler, Pulsed*
Vascular Resistance

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