Document Detail

Late spontaneous dissociation of a fluocinolone acetonide implant (Retisert).
MedLine Citation:
PMID:  23323586     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To describe a case of spontaneous dissociation of a fluocinolone acetonide implant (Retisert) 5 years following implantation.
DESIGN: Case report.
METHODS: A patient with chronic uveitis underwent placement of a fluocinolone acetonide implant in the right eye in 2006. The patient's inflammation was well controlled and did not recur, so the device was not replaced.
RESULTS: Five years after implantation, the patient presented with a new complaint of a shadow in his vision. The drug pellet was found to have separated spontaneously from the anchoring strut and was floating in the vitreous. Pars plana vitrectomy was performed with removal of the drug pellet, and the anchoring strut was left in place.
CONCLUSIONS: Spontaneous intraocular dissociation of a fluocinolone acetonide implant (Retisert) can occur years after placement, in the absence of trauma or other risk factors. Surgeons and patients must be aware of this potential complication as the implants age.
Soraya Rofagha; Tidarat Prechanond; Jay M Stewart
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Publication Detail:
Type:  Case Reports; Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  21     ISSN:  1744-5078     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-07-02     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  77-8     Citation Subset:  IM    
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MeSH Terms
Drug Implants / adverse effects
Fluocinolone Acetonide / administration & dosage*,  pharmacokinetics
Follow-Up Studies
Foreign-Body Migration / diagnosis*,  surgery
Glucocorticoids / administration & dosage
Uveitis / drug therapy*,  metabolism
Vitreous Body
Reg. No./Substance:
0/Drug Implants; 0/Glucocorticoids; 67-73-2/Fluocinolone Acetonide
Erratum In:
Ocul Immunol Inflamm. 2013 Jun;21(3):255

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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