Document Detail

Late revascularization reduces mortality in survivors of myocardial infarction.
MedLine Citation:
PMID:  10423665     Owner:  NLM     Status:  MEDLINE    
In survivors of acute myocardial infarction, the restoration of antegrade flow in the infarct-related coronary artery may improve prognosis by a mechanism that is independent of its influence on left ventricular systolic performance. Furthermore, survival may be improved even when antegrade flow is restored days or even weeks after the acute event. In several retrospective studies of survivors of infarction, we and others have shown a) that long-term survival is substantially better in those with-as opposed to those without-antegrade flow in the infarct-related coronary artery, and b) that the mechanical restoration of flow in an occluded infarct-related artery (accomplished with balloon angioplasty or bypass grafting) markedly improves long-term survival. The late restoration of antegrade flow in the infarct-related artery appears to render the so-called border zone of infarction less electrically unstable, thereby reducing the likelihood of ventricular tachyarrhythmias and sudden death.
L D Hillis; J E Cigarroa; R A Lange
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology in review     Volume:  7     ISSN:  1061-5377     ISO Abbreviation:  Cardiol Rev     Publication Date:    1999 May-Jun
Date Detail:
Created Date:  1999-12-02     Completed Date:  1999-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Department of Internal Medicine (Cardiovascular Division), University of Texas Southwestern Medical Center, Dallas, Texas 75235-9047, USA.
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MeSH Terms
Cause of Death
Coronary Circulation* / physiology*
Death, Sudden, Cardiac / epidemiology,  prevention & control
Middle Aged
Myocardial Infarction / mortality,  physiopathology,  therapy*
Myocardial Revascularization*
Survival Rate
Tachycardia, Ventricular / mortality,  physiopathology,  therapy
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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