| Late reopening of an occluded infarct related artery improves left ventricular function and long term clinical outcome. | |
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MedLine Citation:
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PMID: 15831653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess effects on left ventricular (LV) function and on long term clinical outcome of late percutaneous transluminal coronary angioplasty (PTCA) of a chronically occluded infarct related artery. METHODS: 65 patients who underwent PTCA a mean (SD) of 6.0 (1.2) months after a previous myocardial infarction were divided in two groups according to dilated artery patency status after PTCA: group 1 (35 patients with TIMI (thrombolysis in myocardial infarction) grade 3 flow) and group 2 (30 patients with TIMI grade 0-2 flow). Echocardiography was performed at admission and at six months' follow up. A three year follow up was conducted with major adverse cardiac events (MACE) as end points. RESULTS: At follow up, group 1 had improved global LV ejection fraction (48.7% v 43.6%, p < 0.001) and LV indexed end diastolic and end systolic volumes (75 v 86 ml/m(2) and 40 v 53 ml/m(2), respectively, p = 0.011) compared with group 2. Kaplan-Meier analysis showed a higher incidence of cardiac death (p = 0.02) and MACE (p < 0.0001) in group 2. TIMI 3 after PTCA was an independent predictor of event-free survival at follow up. CONCLUSION: Late PTCA of a chronically occluded infarct related artery improves LV function, reduces cardiac death, and improves long term clinical outcome. |
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Authors:
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F Piscione; G Galasso; G De Luca; G Marrazzo; G Sarno; O Viola; D Accardo; M Chiariello |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 91 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-15 Completed Date: 2005-05-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 646-51 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Federico II University, Naples, Italy. piscione@unina.it <piscione@unina.it> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary
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methods,
mortality Coronary Angiography / methods Coronary Restenosis / prevention & control Coronary Stenosis / therapy*, ultrasonography Death, Sudden, Cardiac / etiology Disease-Free Survival Echocardiography / methods Female Follow-Up Studies Humans Male Middle Aged Myocardial Infarction / therapy*, ultrasonography Myocardial Reperfusion / methods, mortality Treatment Outcome Ventricular Dysfunction, Left / prevention & control*, ultrasonography |
| Comments/Corrections | |
Comment In:
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Heart. 2005 May;91(5):561-2
[PMID:
15831630
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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