| Late regeneration of infarcted small bowel mucosa: a case report. | |
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MedLine Citation:
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PMID: 15772392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ischemic injury of the small bowel may recover after revascularization, provided that full-thickness infarction did not occur. Animal studies showed that if the mucosal crypts remain viable, rapid mucosal restitution occurs hours after injury. The treatment of transmucosal infarction that does not extend to full wall thickness, however, was not investigated thoroughly. The patient presented had a mesenteric event leading to resection of about half of his small bowel. The unresected segment had severe ischemic injury, which seemed to cause transmucosal, but not transmural, infarction. Imaging of the remaining small bowel revealed a seromuscular layer denuded of mucosa. The ischemic damage was too deep to allow rapid regeneration, and the patient had short-bowel syndrome. A year later, during operation for stricture complications, new mucosa covered parts of the small-bowel surface, encouraging the surgeon to elect a conservative approach. Sixteen months after the injury, normal mucosa covered the entire small bowel, and enteral feeding resumed successfully. This report shows that infarcted small-bowel mucosa may regenerate even months after injury. |
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Authors:
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Oded Zmora; Marat Khaikin; Danny Rosin; Moshe Shabtai; Barak Bar-Zakai; Amram Ayalon |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 29 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 2005 Mar-Apr |
Date Detail:
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Created Date: 2005-03-17 Completed Date: 2005-09-01 Revised Date: 2007-02-21 |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 131-3 Citation Subset: IM |
Affiliation:
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Department of Surgery and Transplantation, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv, Israel. ozmora@post.tau.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Anastomosis, Surgical Enteral Nutrition Humans Intestinal Mucosa / physiology* Intestine, Small / blood supply*, physiology, surgery* Ischemia / pathology* Male Middle Aged Regeneration* Short Bowel Syndrome / surgery Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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