Document Detail


Late pulmonary haemodynamic changes in heart-lung transplantation.
MedLine Citation:
PMID:  1600989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As survival improves following heart-lung transplantation (HLT) the importance of obliterative bronchiolitis (OB) as a cause of late death increases. Whilst coronary occlusive disease (COD) may be less common in heart-lung transplant recipients than in patients receiving heart transplants, COD associated with OB can be lethal. We have studied 22 long-term survivors of heart-lung transplantation at an average of 25 months following transplantation during rest and at 50 W supine exercise and with prostacyclin induced vasodilation. Cardiac index increased less with exercise as the physiological measurement of OB using forced expiratory volume in one second (FEV1) fell (P = 0.018). Although resting pulmonary vascular resistance increased with falling FEV1, this increase was still within the normal range. We conclude that a fall in cardiac reserve on exercise accompanies the fall in FEV1 which characterizes OB and may reflect cardiac vascular disease.
Authors:
J P Scott; B A Otulana; P A Mullins; D J Aravoj; T Higenbottam; J Wallwork
Related Documents :
15019639 - Lung transplantation for lymphangioleiomyomatosis.
12581769 - Risk factors and management of bleeding associated with transbronchial lung biopsy in l...
15818209 - Unusual late pulmonary complication in a child after umbilical cord blood transplantati...
10177219 - Aerosol bolus dispersion in patients with bronchiolitis obliterans after heart-lung and...
11782769 - Successful allotransplantation of cryopreserved tracheal grafts with preservation of th...
11889419 - Prevention of bronchiolitis obliterans in rat lung allografts by type v collagen-induce...
9662959 - Infection by cryptosporidium parvum in renal patients submitted to renal transplant or ...
17072799 - Medical complications after lung transplantation.
23352619 - Rectovesical ligament and fusion defect of the uterus with or without obstructed hemiva...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  13     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-14     Completed Date:  1992-07-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  503-7     Citation Subset:  IM    
Affiliation:
Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Bronchiolitis Obliterans / diagnosis,  physiopathology*
Cardiac Output / physiology
Exercise Test*
Female
Follow-Up Studies
Forced Expiratory Volume / physiology*
Graft Rejection / physiology
Heart-Lung Transplantation / physiology*
Hemodynamics / physiology*
Humans
Male
Middle Aged
Oxygen / blood
Postoperative Complications / diagnosis,  physiopathology*
Pulmonary Circulation / physiology*
Risk Factors
Total Lung Capacity / physiology
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Residual atrial septal defects following balloon mitral valvuloplasty using different techniques. A ...
Next Document:  Valve replacement in octogenarians: increased early mortality but good long-term result.