Document Detail

Late pulmonary haemodynamic changes in heart-lung transplantation.
MedLine Citation:
PMID:  1600989     Owner:  NLM     Status:  MEDLINE    
As survival improves following heart-lung transplantation (HLT) the importance of obliterative bronchiolitis (OB) as a cause of late death increases. Whilst coronary occlusive disease (COD) may be less common in heart-lung transplant recipients than in patients receiving heart transplants, COD associated with OB can be lethal. We have studied 22 long-term survivors of heart-lung transplantation at an average of 25 months following transplantation during rest and at 50 W supine exercise and with prostacyclin induced vasodilation. Cardiac index increased less with exercise as the physiological measurement of OB using forced expiratory volume in one second (FEV1) fell (P = 0.018). Although resting pulmonary vascular resistance increased with falling FEV1, this increase was still within the normal range. We conclude that a fall in cardiac reserve on exercise accompanies the fall in FEV1 which characterizes OB and may reflect cardiac vascular disease.
J P Scott; B A Otulana; P A Mullins; D J Aravoj; T Higenbottam; J Wallwork
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  13     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-14     Completed Date:  1992-07-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  503-7     Citation Subset:  IM    
Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge, U.K.
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MeSH Terms
Bronchiolitis Obliterans / diagnosis,  physiopathology*
Cardiac Output / physiology
Exercise Test*
Follow-Up Studies
Forced Expiratory Volume / physiology*
Graft Rejection / physiology
Heart-Lung Transplantation / physiology*
Hemodynamics / physiology*
Middle Aged
Oxygen / blood
Postoperative Complications / diagnosis,  physiopathology*
Pulmonary Circulation / physiology*
Risk Factors
Total Lung Capacity / physiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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