| Late presentation of opsoclonus-myoclonus-ataxia syndrome in a child with stage 4S neuroblastoma. | |
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MedLine Citation:
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PMID: 15956891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Opsoclonus-myoclonus-ataxia syndrome (OMA) in children is most commonly associated with occult neuroblastoma (NB). Although children with OMA and NB have decreased mortality, they suffer from increased neurologic morbidity. The pathogenesis of OMA in NB is not well understood, but current research and treatments support an immune-mediated process. The authors describe an unusual presentation of OMA occurring following 6 months of chemotherapy in a child with stage 4S NB who presented with partial Horner syndrome. Histopathologic examination of his primary cervical tumor showed NB maturation, which may have played a role in precipitating OMA syndrome. Further study of unusual cases of OMA in NB may provide better understanding of the syndrome and additional treatment options for these children. |
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Authors:
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Linsey S Mutch; Donna L Johnston |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 27 ISSN: 1077-4114 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-15 Completed Date: 2005-07-27 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 341-3 Citation Subset: IM |
Affiliation:
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Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ataxia
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etiology* Humans Immunoglobulins, Intravenous / therapeutic use Infant Male Neuroblastoma / diagnosis*, drug therapy* Paraneoplastic Syndromes, Nervous System / etiology* Prednisone / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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