Document Detail


Late pregnancy associated plasma protein A levels decrease in preterm labor.
MedLine Citation:
PMID:  21557695     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. The purpose of the present study is to evaluate late, 'at admission', Pregnancy-associated plasma protein-A (PAPP-A) levels as a predictor of preterm birth in women with complaints of preterm labor or preterm painful contractions. Methods. Prospective cohort study of singleton gestations, 23-37 weeks, and symptoms of preterm labor. Primary end point was delivery < 37 weeks. Predictive PAPP-A values were calculated both for preterm delivery and threatened preterm delivery on receiver operator curve. Results. In all, 41 women (38.3%) delivered before 37 weeks (Group 1); 32 women (30.7%) had symptoms of preterm labor but did not deliver preterm (Group 2); 31 women (29.7%) delivered term (Group 3, control). Mean PAPP-A levels in preterm-labor and its matched control were 33.4 ± 19.9 and 52.5 ± 25.4 mIU/ml, respectively, and difference was statistically significant (p = 0.003). Mean PAPP-A level in threatened preterm labor group was 47.6 ± 25.3 mIU/ml and difference was significant compared to preterm-labor, but not significant compared to control group (p = 0.028 and p = 0.74, respectively). Conclusion. Late PAPP-A levels decreased in preterm labor, levels < 29.8 mIU/ml was associated with increased risk for preterm birth, supporting active management whereas cutoff value of 33.6 mIU/ml is useful for discrimination of preterm birth from threatened preterm birth reaching to term.
Authors:
Alev Atis; Turkan Tandogan; Yavuz Aydin; Cihat Sen; Fatma Turgay; Nezaket Eren; Nimet Goker
Related Documents :
11617225 - Premature mortality in the republic of ireland.
14508895 - New perspectives on nutrition enhance outcomes for premature infants.
17079555 - Genetic susceptibility to retinopathy of prematurity.
1099445 - Efficacy of 17alpha-hydroxyprogesterone caproate in the prevention of premature labor.
24111285 - A new ecological method for the estimation of nutritive sucking efficiency in newborns:...
8740125 - Management of the isolated congenital tracheo-oesophageal fistula.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-11
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Trace elements' concentrations in maternal and umbilical cord plasma at term gestation: a comparison...
Next Document:  Paraoxonase-1 is not affected in polycystic ovary syndrome without metabolic syndrome and insulin re...