Document Detail


Late outcomes of drug-eluting versus bare metal stents in saphenous vein grafts: Propensity score analysis.
MedLine Citation:
PMID:  18412239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare late outcomes with the routine use of drug-eluting stents (DES) compared with bare-metal stents (BMS) during percutaneous intervention (PCI) of saphenous vein grafts (SVGs). BACKGROUND: Safety concerns >1 year from stent implantation have been raised about DES used for PCI of SVGs in a small randomized clinical trial. However, there are few studies comparing late outcomes of DES and BMS in routine clinical practice. METHODS: Clinical outcomes (nonfatal MI, cardiac mortality) were assessed in 74 consecutive patients who received BMS and 74 consecutive propensity score matched patients that received DES for PCI of SVGs. Clinical follow-up was censored at 2 years +/- 30 days for both stent groups. RESULTS: At 2 years, the hazard ratio for DES compared with BMS for PCI of SVGs for target vessel revascularization was 0.54 (0.21-1.36), nonfatal MI or cardiac death was 0.68 (0.27-1.68), cardiac mortality 1.19 (0.32-4.45), and stent thrombosis 0.49 (0.09-2.66). Similar outcomes were observed stratified by propensity score quintile. CONCLUSIONS: The routine clinical use of DES for PCI of SVGs was associated with a safety profile that was similar to that of bare metal stents with a clear trend toward a less frequent need for reinterventions.
Authors:
Robert J Applegate; Matthew Sacrinty; Michael Kutcher; Renato Santos; Sanjay Gandhi; William Little
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  72     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-10-09     Revised Date:  2009-01-27    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
Affiliation:
Wake Forest University School of Medicine, Section of Cardiology, Winston-Salem, North Carolina 27157-1045, USA. bapplega@wfubmc.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Angioplasty, Transluminal, Percutaneous Coronary*
Drug-Eluting Stents*
Equipment Design
Female
Follow-Up Studies
Graft Occlusion, Vascular / diagnosis,  etiology,  therapy*
Humans
Immunosuppressive Agents / administration & dosage
Male
Middle Aged
Myocardial Ischemia / etiology,  mortality,  therapy*
Saphenous Vein / transplantation*
Time Factors
Treatment Outcome
Tubulin Modulators / administration & dosage
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Tubulin Modulators
Comments/Corrections
Comment In:
Catheter Cardiovasc Interv. 2008 Nov 15;72(6):815-8   [PMID:  19006238 ]
Catheter Cardiovasc Interv. 2008 Jul 1;72(1):21-2   [PMID:  18561144 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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