| Late outcomes of drug-eluting versus bare metal stents in saphenous vein grafts: Propensity score analysis. | |
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MedLine Citation:
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PMID: 18412239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare late outcomes with the routine use of drug-eluting stents (DES) compared with bare-metal stents (BMS) during percutaneous intervention (PCI) of saphenous vein grafts (SVGs). BACKGROUND: Safety concerns >1 year from stent implantation have been raised about DES used for PCI of SVGs in a small randomized clinical trial. However, there are few studies comparing late outcomes of DES and BMS in routine clinical practice. METHODS: Clinical outcomes (nonfatal MI, cardiac mortality) were assessed in 74 consecutive patients who received BMS and 74 consecutive propensity score matched patients that received DES for PCI of SVGs. Clinical follow-up was censored at 2 years +/- 30 days for both stent groups. RESULTS: At 2 years, the hazard ratio for DES compared with BMS for PCI of SVGs for target vessel revascularization was 0.54 (0.21-1.36), nonfatal MI or cardiac death was 0.68 (0.27-1.68), cardiac mortality 1.19 (0.32-4.45), and stent thrombosis 0.49 (0.09-2.66). Similar outcomes were observed stratified by propensity score quintile. CONCLUSIONS: The routine clinical use of DES for PCI of SVGs was associated with a safety profile that was similar to that of bare metal stents with a clear trend toward a less frequent need for reinterventions. |
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Authors:
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Robert J Applegate; Matthew Sacrinty; Michael Kutcher; Renato Santos; Sanjay Gandhi; William Little |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 72 ISSN: 1522-726X ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-23 Completed Date: 2008-10-09 Revised Date: 2009-01-27 |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 7-12 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley-Liss, Inc. |
Affiliation:
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Wake Forest University School of Medicine, Section of Cardiology, Winston-Salem, North Carolina 27157-1045, USA. bapplega@wfubmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angioplasty, Transluminal, Percutaneous Coronary* Drug-Eluting Stents* Equipment Design Female Follow-Up Studies Graft Occlusion, Vascular / diagnosis, etiology, therapy* Humans Immunosuppressive Agents / administration & dosage Male Middle Aged Myocardial Ischemia / etiology, mortality, therapy* Saphenous Vein / transplantation* Time Factors Treatment Outcome Tubulin Modulators / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Tubulin Modulators |
| Comments/Corrections | |
Comment In:
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Catheter Cardiovasc Interv. 2008 Nov 15;72(6):815-8
[PMID:
19006238
]
Catheter Cardiovasc Interv. 2008 Jul 1;72(1):21-2 [PMID: 18561144 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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