Document Detail

Late origin of glia-restricted progenitors in the developing mouse cerebral cortex.
MedLine Citation:
PMID:  19363148     Owner:  NLM     Status:  MEDLINE    
In order to unravel the molecular determinants of cell fate, it is important to understand when fate restriction occurs during brain development. Lineage analysis suggested that bi- or multipotent progenitors persist into late developmental stages in some central nervous system regions, whereas most progenitor cells in the cerebral cortex appeared to be restrained to generate only a single cell type already at early stages. Here we discuss this previous work and present new data demonstrating that cortical progenitors generating exclusively glial cells appear late in development. In utero transduction of cortical progenitors at early and mid-neurogenesis using a combination of replication-defective retroviral vectors encoding different fluorescent proteins indicated that the early developing cortex is devoid of glia-restricted progenitors, although these are frequent during mid- and late neurogenesis. Clonal analyses in vitro using retroviral vectors and live cell tracking by video time-lapse microscopy confirmed these findings, revealing that the early developing cortex harbors 2 main progenitor types: neuron-restricted and bipotent (neuron-glial) progenitors. The latter are responsible for the generation of glial-restricted progenitors at mid- and late neurogenesis.
Marcos R Costa; Oliver Bucholz; Timm Schroeder; Magdalena Götz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-04-10
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  19 Suppl 1     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  i135-43     Citation Subset:  IM    
Institute for Stem Cell Research, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany.
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MeSH Terms
Cell Differentiation
Cerebral Cortex / cytology*,  embryology*,  physiology
Neurogenesis / physiology*
Neuroglia / cytology*,  physiology*
Stem Cells / cytology*,  physiology*

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