Document Detail

Late onset and rapid progression of cerebellar abiotrophy in a domestic shorthair cat.
MedLine Citation:
PMID:  20136999     Owner:  NLM     Status:  MEDLINE    
A two-year-old male domestic shorthair cat was seen because of sudden onset of incoordination and tremors that had rapidly worsened over five days. Neurological examination revealed severe cerebellar ataxia, intention tremors and bilaterally decreased menace response. Blood work evaluation included a complete cell blood count (CBC), serum biochemistry profile, urinalysis, faecal flotation, cerebrospinal fluid (CSF) analysis and retroviral testing. Except for testing positive for feline immunodeficiency virus (FIV) antibodies, all other results were within the normal range. The patient was euthanased two days later because of progression of clinical signs, and a necropsy was performed. Histologically, lesions were limited to the cerebellum and consistent with cerebellar abiotrophy. No secondary diseases that could explain the rapid development of clinical signs were found. It was considered unlikely that cerebellar degeneration was related to FIV positivity, as virus invasion of the central nervous system (CNS) is mainly limited to the cerebral cortex. This case report is the first to describe late onset and rapid progression cerebellar abiotrophy in a cat.
C Biolatti; P Gianella; M T Capucchio; A Borrelli; A D'Angelo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of small animal practice     Volume:  51     ISSN:  1748-5827     ISO Abbreviation:  J Small Anim Pract     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0165053     Medline TA:  J Small Anim Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  IM    
Department of Animal Pathology, Clinical Section, University of Turin, Via L. da Vinci 44, 10095 Grugliasco (TO), Italy.
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MeSH Terms
Age of Onset
Cat Diseases / diagnosis*,  pathology
Cerebellar Ataxia / diagnosis,  pathology,  veterinary*
Diagnosis, Differential
Disease Progression
Fatal Outcome
Feline Acquired Immunodeficiency Syndrome / diagnosis,  pathology

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