Document Detail


Late onset neonatal anaemia due to maternal anti-Ge: possible association with destruction of eythroid progenitors.
MedLine Citation:
PMID:  15859979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There have been no reports of severe haemolytic disease of the newborn (HDN) due to Gerbich (Ge) antibodies. Two babies with HDN due to anti-Ge3, both born to the same mother, are described. The anti-Ge appeared in the first pregnancy and was not detectable in the first trimester, the babies' reticulocyte and bilirubin values were not greatly elevated (similar to HDN due to Kell antibodies), and the anaemia in both cases was either not apparent or not severe until 2 to 4 weeks after birth. Ge antigens are found on glycophorins (GPs) C and D; GPC, like Kell, has been shown to be expressed early on erythroid progenitor cells. The maternal anti-Ge3 was shown to promote phagocytosis of Ge+ early erythroid progenitors by monocytes (similar to what has been reported with anti-K and K+ progenitor cells). Thus, anti-Ge3 may cause immune destruction of erythroid progenitors and possibly suppression of erythropoiesis (which would explain the reticulocyte and bilirubin values seen in both cases). Anti-Ge3 appears to be capable of causing severe HDN. We suggest that babies born to mothers with anti-Ge should have their haemoglobin concentrations monitored for signs of anaemia for several weeks after birth. Functional assays may prove useful.
Authors:
P A Arndt; G Garratty; G Daniels; C A Green; A M Wilkes; P Hunt; J Do; S Glenn; D Peterson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transfusion medicine (Oxford, England)     Volume:  15     ISSN:  0958-7578     ISO Abbreviation:  Transfus Med     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-29     Completed Date:  2005-09-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9301182     Medline TA:  Transfus Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
Affiliation:
American Red Cross Blood Services, Pomona, CA 90006, USA. arndtp@usa.redcross.org
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MeSH Terms
Descriptor/Qualifier:
Anemia, Hemolytic / immunology*
Blood Group Antigens / immunology*
Blood Group Incompatibility / immunology*,  pathology
Erythroid Precursor Cells / immunology*
Erythropoiesis / immunology
Female
Glycophorin / immunology*
Humans
Infant, Newborn
Infant, Newborn, Diseases / immunology,  pathology
Isoantibodies / immunology*
Male
Maternal-Fetal Exchange / immunology*
Pregnancy / immunology
Chemical
Reg. No./Substance:
0/Blood Group Antigens; 0/Glycophorin; 0/Isoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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