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Late onset lupus nephritis: analysis of clinical manifestations and renal pathological features in Chinese patients.
MedLine Citation:
PMID:  20535471     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The objectives of the study are to analyze the clinical and pathological features of 35 Chinese patients with late onset lupus nephritis (LN) in a single center. All the LN patients followed-up in our lupus clinic center from 1986 to 2008 were enrolled in this retrospective study. Thirty-five patients with a disease onset beyond the age of 50 years were identified. One hundred systemic lupus erythematosus (SLE) patients who had their disease onset before the age of 50 years were randomly recruited as controls. All of them received renal biopsy. The histological classifications were categorized according to 2003 International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification. All of patients were Han Chinese. The mean age of onset of SLE for late onset and the control groups were 55.7 ± 6.5 years (range: 50-76) and 28.9 ± 7.6 years (range:18-48).The female to male ratio was smaller in the late onset SLE group, 2.9-1, compared with 7.3-1 in the control. The patients with hypertension in late onset LN were much more than that in control group. The renal histological classes showed no significant difference between the two groups. Classes IV, V, IV + V were common in late onset LN patients. There were no significant differences in extra renal manifestations except for a lower prevalence of malar rash, a higher leukopenia and skin vasculitis in the late onset patients. As to the immunological features, serum antineutrophil cytoplasmic antibodies (ANCA) and SSA positivity were more common in late onset LN patients. The patients with hypertension in late onset LN were much more than that in control group. The renal histological classes showed no significant difference between the two groups. Leukopenia and serum ANCA were more common. The results suggest a more severity of the disease in late onset LN.
Authors:
Zheng Tang; Dongmei Chen; Shengmei Yang; Haitao Zhang; Weixin Hu; Zhihong Liu; Leishi Li
Publication Detail:
Type:  Journal Article     Date:  2010-06-10
Journal Detail:
Title:  Rheumatology international     Volume:  31     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1625-9     Citation Subset:  IM    
Affiliation:
Research Institute of Nephrology, Jingling Hospital, Nanjing University School of Medicine, 210002, Nanjing, China, tangdr@public1.ptt.js.cn.
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