| Late-onset Fanconi anemia in an African-Caribbean patient. | |
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MedLine Citation:
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PMID: 20191926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 38-year-old female of African-Caribbean origin presented with symptomatic anemia and was found to have hypoplastic thumbs and patchy hypopigmentation. Peripheral blood examination revealed pancytopenia and the bone marrow biopsy confirmed marrow hypoplasia. Fanconi anemia was later confirmed by flow cytometry and diepoxybutane testing. Treatment was limited to transfusions after development of toxicity with cyclosporine and androgen therapy. She manifested classical features of transfusion-related hemosiderosis and died 12 years after initial presentation. |
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Authors:
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Roslyn Alfred; Loretta Buchner-Daley; Adedamola Soyibo; Doreen Brady-West; Rochelle Hardie; Donovan McGrowder |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the National Medical Association Volume: 102 ISSN: 0027-9684 ISO Abbreviation: J Natl Med Assoc Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503090 Medline TA: J Natl Med Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 132-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Blood Transfusion Fanconi Anemia / diagnosis*, epidemiology, therapy Female Humans Iron Chelating Agents / therapeutic use Jamaica Thumb / abnormalities |
| Chemical | |
Reg. No./Substance:
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0/Iron Chelating Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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