Document Detail


Late normalisation of uterine artery velocimetry in high risk pregnancy.
MedLine Citation:
PMID:  11267718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test whether late normalisation of abnormal uterine velocimetry is a favourable prognostic factor in high risk pregnancies. STUDY DESIGN: Uterine artery colour Doppler velocimetry was performed at 24, 28-30 and 32-34 weeks in 282 high risk pregnancies treated with low dose aspirin. RESULTS: 88 patients had abnormal waveforms at 24 weeks and 77 delivered after the second assessment at 28 weeks. Of these, 38 (49%) had a normalisation of Doppler indices by 34 weeks. Compared with the persistently abnormal Doppler group, these patients delivered fewer small for gestational age babies (5/38 versus 26/39; p=0.0001) and had less gestational hypertension without proteinuria (3/38 versus 15/39; p=0.004). No patients with preeclampsia or other severe complications of pregnancy were observed in the normalised group. CONCLUSIONS: Although abnormal uterine artery velocimetry at 24 weeks is predictive of adverse pregnancy outcome, nearly half have late normalisation of the Doppler indices and a better perinatal outcome. Persistently abnormal waveforms are related to the worst pregnancy outcome.
Authors:
M Soregaroli; A Valcamonico; L Scalvi; L Danti; T Frusca
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  95     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-27     Completed Date:  2001-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  42-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Brescia, Piazzale Spedali Civili 1, 25100, Brescia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Arteries / physiology,  ultrasonography
Aspirin / administration & dosage
Blood Flow Velocity
Dose-Response Relationship, Drug
Female
Fetal Death
Humans
Hypertension / physiopathology
Infant, Newborn
Infant, Small for Gestational Age
Pre-Eclampsia / physiopathology
Predictive Value of Tests
Pregnancy
Pregnancy Complications, Cardiovascular / drug therapy,  physiopathology*
Pregnancy, High-Risk / physiology*
Ultrasonography, Doppler, Color / methods
Ultrasonography, Prenatal / methods
Uterus / blood supply*,  ultrasonography
Chemical
Reg. No./Substance:
50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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