| Late normalisation of uterine artery velocimetry in high risk pregnancy. | |
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MedLine Citation:
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PMID: 11267718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test whether late normalisation of abnormal uterine velocimetry is a favourable prognostic factor in high risk pregnancies. STUDY DESIGN: Uterine artery colour Doppler velocimetry was performed at 24, 28-30 and 32-34 weeks in 282 high risk pregnancies treated with low dose aspirin. RESULTS: 88 patients had abnormal waveforms at 24 weeks and 77 delivered after the second assessment at 28 weeks. Of these, 38 (49%) had a normalisation of Doppler indices by 34 weeks. Compared with the persistently abnormal Doppler group, these patients delivered fewer small for gestational age babies (5/38 versus 26/39; p=0.0001) and had less gestational hypertension without proteinuria (3/38 versus 15/39; p=0.004). No patients with preeclampsia or other severe complications of pregnancy were observed in the normalised group. CONCLUSIONS: Although abnormal uterine artery velocimetry at 24 weeks is predictive of adverse pregnancy outcome, nearly half have late normalisation of the Doppler indices and a better perinatal outcome. Persistently abnormal waveforms are related to the worst pregnancy outcome. |
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Authors:
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M Soregaroli; A Valcamonico; L Scalvi; L Danti; T Frusca |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 95 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-27 Completed Date: 2001-07-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 42-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Brescia, Piazzale Spedali Civili 1, 25100, Brescia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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physiology,
ultrasonography Aspirin / administration & dosage Blood Flow Velocity Dose-Response Relationship, Drug Female Fetal Death Humans Hypertension / physiopathology Infant, Newborn Infant, Small for Gestational Age Pre-Eclampsia / physiopathology Predictive Value of Tests Pregnancy Pregnancy Complications, Cardiovascular / drug therapy, physiopathology* Pregnancy, High-Risk / physiology* Ultrasonography, Doppler, Color / methods Ultrasonography, Prenatal / methods Uterus / blood supply*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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