| Late-night salivary cortisol in normal subjects and in patients with Cushing's syndrome. | |
| | |
MedLine Citation:
|
PMID: 20634249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Late-night salivary cortisol is used as a screening test for Cushing's syndrome (CS) in many European and American countries. However, its utility has not been studied in an Asian-Indian population. OBJECTIVE: To establish the reference range in Asian-Indians and to evaluate its usefulness in the diagnosis of CS. METHODS: Three groups of subjects were studied: normal subjects, patients with suspected CS, and patients with proven CS. All participants collected saliva at 23:00 h using a Salivette. Salivary cortisol was measured using an automated electrochemiluminescence assay. RESULTS: There were 56 normal subjects, 40 patients with suspected CS, and 30 with proven CS. Of the 40 with suspected CS, three were confirmed to have CS. The remaining 37 served as control patients. The 97.5th centile of the late-night salivary cortisol concentrations in normal subjects was 10.87 nmol/l. The mean+/-SD 23:00 h salivary cortisol concentration in control patients and those with confirmed CS was 3.21+/-2.36 nmol/l and 32.33+/-44.14 nmol/l, respectively. All the control patients and 30.3% (10/33) of patients with CS had a salivary cortisol concentration of <10.87 nmol/l. With the use of a receiver operating characteristic curve, a cut-off of 4.55 nmol/l gave a sensitivity of 93.9% and specificity of 81.1%. However, as this cut-off is less than the functional sensitivity of the assay, it may not be clinically applicable. CONCLUSIONS: The reference range for late-night salivary cortisol in our population was <10.87 nmol/l. With this cut-off, the sensitivity was 69.2% and specificity 100%. Even though this automated electrochemiluminescence assay is easy and quick to use, its clinical utility in measuring the low salivary cortisol concentrations needs further investigation. |
| | |
Authors:
|
K Jeyaraman; A C Ammini; G Nandita; S N Dwivedi |
Related Documents
:
|
18214589 - The role of unilateral adrenalectomy in acth-independent macronodular adrenal hyperplas... 6803489 - Glycoprotein hormone alpha-subunit secretion in patients with pituitary adenomas: influ... 9849709 - Glucocorticoid receptors on mononuclear leukocytes in polycystic ovary syndrome. 17090639 - Antipituitary antibodies against gonadotropin-secreting cells in adult male patients wi... 3118729 - Growth hormone response to grf 1-44 in children following cranial irradiation for centr... 3766049 - Transsphenoidal microsurgery for cushing's disease. 7589679 - Characteristics of blood hemostatic markers in a patient with ovarian hyperstimulation ... 2766079 - Computed tomography as a diagnostic aid in diabetic and other problem feet. 17442739 - Focal segmental glomerulosclerosis is not a sufficient predictor of renal outcome in pa... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article |
Journal Detail:
|
Title: Postgraduate medical journal Volume: 86 ISSN: 1469-0756 ISO Abbreviation: Postgrad Med J Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-16 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: England |
Other Details:
|
Languages: eng Pagination: 399-404 Citation Subset: IM |
Affiliation:
|
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, 3074, Third Floor, Teaching Block, Ansari nagar, New Delhi, India. kanakamani@rediffmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Asian Continental Ancestry Group / ethnology* Circadian Rhythm / physiology Cushing Syndrome / diagnosis*, ethnology Female Humans Hydrocortisone / metabolism* Male Reference Values Saliva / chemistry* Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Feasibility and safety of outpatient radiofrequency catheter ablation procedures for atrial fibrilla...
Next Document: Chronic kidney disease presenting acutely: presentation, clinical features and outcome of patients w...