| Late neurocognitive sequelae in patients with WHO grade I meningioma. | |
| | |
MedLine Citation:
|
PMID: 18653549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Information on neurocognitive outcome following treatment of benign meningiomas is virtually lacking. This is remarkable considering that survival in these patients is the most favourable of all intracranial tumours. The aim of the present study was therefore to document the extent and nature of neurocognitive deficits in patients with World Health Organization (WHO) grade I meningioma after treatment. METHODS: 89 patients with WHO grade I meningioma who underwent surgery with or without adjuvant radiotherapy were individually matched to 89 healthy controls for age, sex and educational level. Neurocognitive functioning of patients was assessed at least 1 year following treatment and compared with that of healthy controls using the Student's t test. Additionally, associations between tumour characteristics (size, lateralisation and localisation), treatment characteristics (radiotherapy) and epilepsy burden (based on seizure frequency and antiepileptic drug use) and neurocognitive functioning were investigated. RESULTS: Compared with healthy controls, patients with meningioma showed significant impairments in executive functioning (p<0.001), verbal memory (p<0.001), information processing capacity (p = 0.001), psychomotor speed (p = 0.001) and working memory (p = 0.006). Patients with skull base meningiomas performed significantly lower on three out of six neurocognitive domains compared with convexity meningiomas. Left-sided as opposed to right-sided meningiomas were related to verbal memory deficits. A higher epilepsy burden was significantly associated with lower executive functioning which primarily could be attributed to antiepileptic drug use. No significant associations were established between neurocognitive status and radiotherapy or tumour volume. CONCLUSIONS: Meningioma patients are characterised by long term deficits in neurocognitive functioning that can partly be attributed to the use of antiepileptic drugs and tumour location but not to the use of radiotherapy. |
| | |
Authors:
|
M Dijkstra; D van Nieuwenhuizen; L J A Stalpers; M Wumkes; M Waagemans; W P Vandertop; J J Heimans; S Leenstra; C M Dirven; J C Reijneveld; M Klein |
Related Documents
:
|
17876389 - Temporal pole signal abnormality on mr imaging in temporal lobe epilepsy with hippocamp... 14639669 - Perceptual differences in sequential stimuli across patients with musician's and writer... 11134379 - Visual field deficits in conventional anterior temporal lobectomy versus amygdalohippoc... 16014649 - Analysis of shape and positioning of the hippocampal formation: an mri study in patient... 8848199 - Quantitative hippocampal mri and intractable temporal lobe epilepsy. 20223639 - Auras and clinical features in temporal lobe epilepsy: a new approach on the basis of v... 21698509 - Anesthetic management of patients with brugada syndrome: a case series and literature r... 10480289 - Low-dose oral iron absorption test in anaemic patients with and without iron deficiency... 8418719 - Mild hypothermia does not impair postanesthetic recovery in infants and children. |
Publication Detail:
|
Type: Journal Article; Multicenter Study Date: 2008-07-24 |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 80 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-07-17 Completed Date: 2009-07-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
|
Languages: eng Pagination: 910-5 Citation Subset: IM |
Affiliation:
|
Department of Medical Psychology, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Cognition Disorders / etiology* Cross-Sectional Studies Epilepsy / etiology Female Functional Laterality / physiology Humans Male Meningioma / complications*, psychology, therapy Middle Aged Neoplasm Recurrence, Local Neuropsychological Tests Neurosurgical Procedures Psychomotor Performance / physiology Socioeconomic Factors Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Manipulation of skin temperature improves nocturnal sleep in narcolepsy.
Next Document: Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron ...