| Late miscarriage and preterm birth after treatment with clindamycin: a randomised consent design study according to Zelen. | |
| | |
MedLine Citation:
|
PMID: 16709205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To screen for bacterial vaginosis (BV) and to investigate the effect of treatment with vaginal clindamycin in order to observe the effect on late miscarriage and delivery prior to 37 completed weeks (primary outcome). DESIGN: Randomised consent design for clinical trials according to Zelen. SETTING: Southeast region of Sweden. POPULATION: A total of 9025 women were screened in early pregnancy. METHODS: A total of 819 women with a Nugent score of 6 and above were considered to have BV and treated according to Zelen allocation. The incidence of late miscarriage and spontaneous (noniatrogenic) preterm birth was assessed. MAIN OUTCOME MEASURES: Late miscarriage and spontaneous preterm delivery before 37 weeks. RESULTS: Therapy with vaginal clindamycin had no significant impact on the incidence of spontaneous preterm delivery prior to 37 completed weeks; OR 0.90, 95% CI 0.40-2.02 (primary outcome variable). However, only 1 of 11 women in the treatment group versus 5 of 12 in the control group delivered prior to 33 completed weeks; OR 0.14, 95% CI 0.02-0.95. Treatment was associated with 32 days longer gestation for the 23 participants who had late miscarriage or spontaneous preterm birth (P= 0.024, Mann-Whitney U test) and significantly fewer infants had a birthweight below 2,500 g (secondary outcome). A follow up of infants born preterm 4 years postnatally indicated that extending gestational age did not increase the number of sequelae. CONCLUSIONS: Clindamycin vaginal cream therapy was associated with significantly prolonged gestation and reduced cost of neonatal care in women with BV. Early screening for BV and treatment with clindamycin saved approximately 27 euro per woman. |
| | |
Authors:
|
P-G Larsson; L Fåhraeus; B Carlsson; T Jakobsson; U Forsum; |
Related Documents
:
|
8154905 - Infantile hydrocephalus epidemiology: an indicator of enhanced survival. 19922725 - Born a bit too early: recent trends in late preterm births. 19564305 - Delivery indications at late-preterm gestations and infant mortality rates in the unite... 15581155 - Altered pathways for auditory discrimination and recognition memory in preterm infants. 2388775 - Pulmonary function testing prior to extubation in infants with respiratory distress syn... 9417805 - Caregiving to very low birthweight infants: a model of stress and immune response. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: BJOG : an international journal of obstetrics and gynaecology Volume: 113 ISSN: 1470-0328 ISO Abbreviation: BJOG Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-05-19 Completed Date: 2006-07-13 Revised Date: 2007-01-26 |
Medline Journal Info:
|
Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
|
Languages: eng Pagination: 629-37 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, Kärnsjukhuset, Skövde, Sweden. p-g.larsson@vregion.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Spontaneous
/
prevention & control* Adult Anti-Bacterial Agents / therapeutic use* Birth Weight Clindamycin / therapeutic use* Female Humans Infant, Newborn Odds Ratio Pregnancy Pregnancy Outcome Premature Birth / prevention & control* Statistics, Nonparametric Survival Analysis Treatment Outcome Vaginosis, Bacterial / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 18323-44-9/Clindamycin |
| Comments/Corrections | |
Comment In:
|
BJOG. 2006 Dec;113(12):1483; author reply 1484
[PMID:
17176286
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regimens of misoprostol with mifepristone for early medical abortion: a randomised trial.
Next Document: Antenatal fear of childbirth and its association with subsequent caesarean section and experience of...