| Late hyporegenerative anemia in neonates with rhesus hemolytic disease. | |
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MedLine Citation:
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PMID: 10379500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted to determine the risk factors of the late hyporegenerative anemia in Rh-isoimmunized infants. Data on 36 infants with rhesus hemolytic disease were analyzed. The mean gestational age and birth weight were 36 +/- 1.3 weeks and 2837 +/- 403 grams respectively. Twenty-seven infants (75%) received between 2 and 8 intravascular intrauterine blood transfusions. Fourteen infants (39%) required simple packed red blood cell transfusions and 11 infants (31%) required exchange blood transfusion in the immediate postnatal period. Thirty infants (83%) developed late anemia and required blood transfusions at a mean postnatal age of 43.3 +/- 15.7 days. Sixty-four percent of infants who had exchange blood transfusions did not develop late anemia, while 92% of infants who did not require exchange blood transfusion developed late anemia, and the difference was statistically significant (P = 0.035). Serum erythropoietin levels were determined in 8 infants immediately before simple transfusion for late anemia. The media serum erythropoietin level was 21.2 mU/ml, ranging between less than 10 to 114.2 mU/ml. We conclude that late hyporegenerative anemia is common among Rh isoimmunized infants, regardless of the intravascular intrauterine transfusion. Exchange blood transfusion was associated with less occurrence of late anemia. |
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Authors:
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S al-Alaiyan; A al Omran |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 27 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 1999 |
Date Detail:
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Created Date: 1999-08-19 Completed Date: 1999-08-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 112-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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etiology*,
therapy Blood Transfusion Blood Transfusion, Intrauterine Erythroblastosis, Fetal / immunology* Exchange Transfusion, Whole Blood Female Fetal Diseases / therapy Humans Infant Infant, Newborn Parity Pregnancy Reticulocyte Count Rh Isoimmunization / complications* |
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