Document Detail

Late hyponatremia in premature infants: role of aldosterone and arginine vasopressin.
MedLine Citation:
PMID:  3998955     Owner:  NLM     Status:  MEDLINE    
To assess the possible involvement of arginine vasopressin in the pathogenesis of late hyponatremia in preterm infants, serial measurements of sodium balance, fractional sodium excretion, plasma and urine osmolality and sodium concentration, and urinary aldosterone and arginine vasopressin excretion were performed at weekly intervals in nine healthy preterm infants. During the course of late hyponatremia, there was a significant increase in urinary aldosterone and arginine vasopressin excretion, from 0.94 +/- 0.16 to 4.30 +/- 0.76 micrograms/day and from 0.38 +/- 0.08 to 1.19 +/- 0.26 ng/day, respectively, from the first to the fourth to fifth weeks. A significant negative correlation was found between fractional sodium excretion and urinary aldosterone excretion. Aldosterone excretion, however, correlated positively with urinary arginine vasopressin excretion in seven of the nine infants. The parallel increase in urinary aldosterone and arginine vasopressin excretion in salt-losing premature infants may occur in response to the protracted contraction of the extracellular fluid compartment, and may contribute to the restoration of volume in the body fluid compartments and to the development of late hyponatremia.
E Sulyok; L Kovács; B Lichardus; N Michajlovskij; V Lehotska; V Némethova; L Varga; T Ertl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  106     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-25     Completed Date:  1985-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  990-4     Citation Subset:  AIM; IM    
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MeSH Terms
Aldosterone / physiology*,  urine
Arginine Vasopressin / physiology*,  urine
Hyponatremia / etiology*
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases* / etiology*
Osmolar Concentration
Sodium / metabolism
Time Factors
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 52-39-1/Aldosterone; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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