| Late hyponatremia in premature infants: role of aldosterone and arginine vasopressin. | |
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MedLine Citation:
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PMID: 3998955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the possible involvement of arginine vasopressin in the pathogenesis of late hyponatremia in preterm infants, serial measurements of sodium balance, fractional sodium excretion, plasma and urine osmolality and sodium concentration, and urinary aldosterone and arginine vasopressin excretion were performed at weekly intervals in nine healthy preterm infants. During the course of late hyponatremia, there was a significant increase in urinary aldosterone and arginine vasopressin excretion, from 0.94 +/- 0.16 to 4.30 +/- 0.76 micrograms/day and from 0.38 +/- 0.08 to 1.19 +/- 0.26 ng/day, respectively, from the first to the fourth to fifth weeks. A significant negative correlation was found between fractional sodium excretion and urinary aldosterone excretion. Aldosterone excretion, however, correlated positively with urinary arginine vasopressin excretion in seven of the nine infants. The parallel increase in urinary aldosterone and arginine vasopressin excretion in salt-losing premature infants may occur in response to the protracted contraction of the extracellular fluid compartment, and may contribute to the restoration of volume in the body fluid compartments and to the development of late hyponatremia. |
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Authors:
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E Sulyok; L Kovács; B Lichardus; N Michajlovskij; V Lehotska; V Némethova; L Varga; T Ertl |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 106 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-07-25 Completed Date: 1985-07-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 990-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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physiology*,
urine Arginine Vasopressin / physiology*, urine Humans Hyponatremia / etiology* Infant, Low Birth Weight Infant, Newborn Infant, Premature, Diseases* / etiology* Male Osmolar Concentration Sodium / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin; 52-39-1/Aldosterone; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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