Document Detail

Late hemorrhagic disease of newborn.
MedLine Citation:
PMID:  12657755     Owner:  NLM     Status:  MEDLINE    
The clinical features of 14 infants diagnosed with late hemorrhagic disease of newborn (LHDN), of which 10 did not receive vitamin K prophylaxis, are presented. All infants were exclusively breast-fed and 12 did not have any underlying illness to explain the abnormal coagulation profile. The common presenting symptoms were seizures (71%), vomiting (57%), poor feeding (50%) and altered sensorium (36%). Physical examination shared pallor in all infants and a bulging anterior fontanel in 64%. Intracranial bleed was the predominant manifestation (93%), with CT scan showing intracranial bleed in 78%. Eight infants (57%) succumbed to their illness, while 36%had neurological sequelae. Since LHDN leads to significant morbidity and mortality, it should be prevented by providing vitamin K prophylaxis to all newborns.
I E D'Souza; S D Subba Rao
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Indian pediatrics     Volume:  40     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-05-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  226-9     Citation Subset:  IM    
Department of Pediatrics, St. John's Medical College Hospital, Bangalore, Karnataka, India.
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MeSH Terms
Infant, Newborn
Time Factors
Vitamin K Deficiency Bleeding / diagnosis*,  prevention & control,  therapy*
Comment In:
Indian Pediatr. 2003 Aug;40(8):793-4; author reply 794-5   [PMID:  12951387 ]

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