| Late gadolinium enhancement of acute myocardial infarction in mice at 7T: cine-FLASH versus inversion recovery. | |
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MedLine Citation:
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PMID: 20882618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate myocardial infarction (MI), late gadolinium (Gd) enhancement (LGE), cardiovascular magnetic resonance imaging (CMRI) is used as the current gold standard for the in vivo diagnosis in patients and preclinical studies. While inversion recovery (IR) fast gradient echo LGE imaging is the preferred technique at clinical field strengths it remains to be investigated which is the best sequence at higher field strength. We therefore compared the IR technique against cine fast low shot angle (cine-FLASH) for the quantification of MI size in mice at 7T in vivo. MATERIALS AND METHODS: Five mice were used to optimize cine-FLASH and IR parameters. Nine mice were subsequently imaged with optimized parameters using both techniques 2-3 days after MI and ≈30 minutes post Gd injection. RESULTS: The difference in infarct size values was within 3.3% between the two CMRI techniques and within 7.5% of histological values by Bland-Altman analysis. Contrast-to-noise-ratio between infarcted and normal tissue as well as blood was higher for cine-FLASH with the additional benefit of a 2-time-fold shorter scan time than with the IR method. Furthermore, left ventricular function/volumes could be calculated from cine-FLASH images before as well as after Gd injection. CONCLUSION: In conclusion, cine-FLASH LGE MRI represents an attractive alternative to IR LGE MRI for infarct size assessment in mice at high field strengths because it provides similar accuracy while being more robust, faster, and less user dependent. |
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Authors:
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Andrea Protti; Alexander Sirker; Ajay M Shah; Rene Botnar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 878-86 Citation Subset: IM |
Affiliation:
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Cardiovascular Division, King's College London British Heart Foundation Centre, London, United Kingdom. andrea.protti@kcl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Computer Simulation Contrast Media / pharmacology Female Gadolinium / diagnostic use* Image Processing, Computer-Assisted / methods Magnetic Resonance Imaging, Cine / methods* Mice Mice, Inbred C57BL Models, Statistical Myocardial Infarction / diagnosis*, pathology* Reproducibility of Results Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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CH/99001//British Heart Foundation; CI/05/003//British Heart Foundation; RE/08/003//British Heart Foundation |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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