Document Detail


Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury.
MedLine Citation:
PMID:  23313314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Delayed secondary biochemical and cellular changes after traumatic brain injury continue for months to years, and are associated with chronic neuroinflammation and progressive neurodegeneration. Physical activity can reduce inflammation and facilitate recovery after brain injury. Here, we investigated the time-dependent effects, and underlying mechanisms of post-traumatic exercise initiation on outcome after moderate traumatic brain injury using a well-characterized mouse controlled cortical impact model. Late exercise initiation beginning at 5weeks after trauma, but not early initiation of exercise at 1week, significantly reduced working and retention memory impairment at 3months, and decreased lesion volume compared to non-exercise injury controls. Cognitive recovery was associated with attenuation of classical inflammatory pathways, activation of alternative inflammatory responses and enhancement of neurogenesis. In contrast, early initiation of exercise failed to alter behavioral recovery or lesion size, while increasing the neurotoxic pro-inflammatory responses. These data underscore the critical importance of timing of exercise initiation after trauma and its relation to neuroinflammation, and challenge the widely held view that effective neuroprotection requires early intervention.
Authors:
Chun-Shu Piao; Bogdan A Stoica; Junfang Wu; Boris Sabirzhanov; Zaorui Zhao; Rainier Cabatbat; David J Loane; Alan I Faden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-08
Journal Detail:
Title:  Neurobiology of disease     Volume:  54     ISSN:  1095-953X     ISO Abbreviation:  Neurobiol. Dis.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-16     Completed Date:  2013-10-21     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9500169     Medline TA:  Neurobiol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  252-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Brain / pathology
Brain Injuries / pathology*,  rehabilitation*
Cognition Disorders / etiology,  pathology,  rehabilitation*
Disease Models, Animal
Immunohistochemistry
Inflammation / pathology,  prevention & control
Mice
Physical Conditioning, Animal / physiology*
Real-Time Polymerase Chain Reaction
Recovery of Function / physiology*
Grant Support
ID/Acronym/Agency:
7R01NS061839-02/NS/NINDS NIH HHS; R01 NS061839/NS/NINDS NIH HHS
Comments/Corrections

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