Document Detail


Late-evening snack with branched-chain amino acids improves liver function after radiofrequency ablation for hepatocellular carcinoma.
MedLine Citation:
PMID:  22380706     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
AIM:   This prospective study was designed to examine whether consumption of a branched-chain amino acid (BCAA)-enriched nutrient mixture as a late-evening snack (LES) helps maintain and/or improve liver functioning in liver cirrhosis (LC) patients who have undergone radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC).
METHODS:   An equal number (10) of 30 LC patients who had undergone RFA for HCC was randomly assigned to a standard diet group (control) group, a morning BCAA (M-BCAA) administration group, or a LES with BCAA (LES-BCAA) administration group. Liver function testing was performed and Child-Pugh scores (CPS) calculated for each group to assess the improvement at 1, 4 and 12 weeks post-RFA.
RESULTS:   Compared to the control and M-BCAA groups, the LES-BCAA group experienced a rapid and significant improvement in albumin and total serum bilirubin levels and in CPS that began during the initial post-RFA period. These results indicate that LES with BCAA supplementation significantly improved the CPS of the LES-BCAA group at 4 and 12 weeks post-RFA. Although no patients experienced serious adverse effects, two patients who had been diagnosed with diabetes mellitus before undergoing RFA required blood sugar management to improve glycemic control and one subject withdrew due to supplement-induced vomiting.
CONCLUSION:   LES with BCAA supplementation significantly and rapidly improves liver functioning and CPS in LC patients who have undergone RFA for HCC. Control of blood sugar levels is necessary when calorie-containing BCAA is administrated to LC patients with impaired glucose tolerance.
Authors:
Daisuke Morihara; Kaoru Iwata; Takayuki Hanano; Hideo Kunimoto; Shizuka Kuno; Atsushi Fukunaga; Kaoru Yotsumoto; Kazuhide Takata; Takashi Tanaka; Kunitoshi Sakurai; Hideyuki Iwashita; Shu-Ichi Ueda; Genryu Hirano; Keiji Yokoyama; Hidetoshi Nakane; Shinya Nishizawa; Makoto Yoshikane; Akira Anan; Yasuaki Takeyama; Shigeru Kakumitsu; Yuji Kitamura; Masaharu Sakamoto; Makoto Irie; Satoshi Shakado; Tetsuro Sohda; Hiroshi Watanabe; Shotaro Sakisaka
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Publication Detail:
Type:  Journal Article     Date:  2012-03-02
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  42     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2013-07-04     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  658-67     Citation Subset:  -    
Copyright Information:
© 2012 The Japan Society of Hepatology.
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