| Late effects of central nervous system treatment of acute lymphoblastic leukemia in childhood are sex-dependent. | |
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MedLine Citation:
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PMID: 2311827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors measured the cognitive function and physical growth of 51 children who had been treated for acute lymphoblastic leukemia with chemotherapy, cranial irradiation and intrathecal methotrexate, and who had remained disease-free for five to 12 years. A comparison group of 15 children treated for Wilms' tumor was also studied. Cognitive impairment and growth retardation were greater among the leukemia group. Of potentially greater significance, however, was the finding that female sex was the pre-eminent risk factor for central nervous system toxicity resulting from treatment. Cognitive impairment, short stature and excessive weight were all more prevalent among females than males. Approximately half the children were microcephalic, but there was no sex difference. Age at evaluation and diagnosis, as well as socio-economic status, were differentially related to outcomes for the two sexes. The authors believe the sex differences were indicative of a fundamental interaction between postnatal neural development and other biological processes. |
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Authors:
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D P Waber; D K Urion; N J Tarbell; C Niemeyer; R Gelber; S E Sallan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 32 ISSN: 0012-1622 ISO Abbreviation: Dev Med Child Neurol Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-04-23 Completed Date: 1990-04-23 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 238-48 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Children's Hospital, Boston, MA 02115. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Height Body Weight Central Nervous System Diseases / etiology*, psychology Child Child, Preschool Cognition Disorders / etiology Combined Modality Therapy Female Humans Injections, Spinal Intelligence Tests Male Precursor Cell Lymphoblastic Leukemia-Lymphoma / psychology, therapy* Sex Factors Socioeconomic Factors |
| Grant Support | |
ID/Acronym/Agency:
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CA34183/CA/NCI NIH HHS; NS22108/NS/NINDS NIH HHS; P30-HD18655/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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