Document Detail

Late dissemination of pulmonary blastomycosis during ketoconazole therapy.
MedLine Citation:
PMID:  2909344     Owner:  NLM     Status:  MEDLINE    
We report a patient with pulmonary blastomycosis who suffered relapse with dissemination of her disease after five months of apparent response to therapy with ketoconazole, 400 mg daily. Common causes of drug failure, including noncompliance and failure of absorption, were excluded, and there was no evidence of altered host immunity. Previous reports of relapse during and after ketoconazole therapy are reviewed; no previous case was found with recurrence near the end of a six-month period of apparently effective therapy. Close followup during the entire course of ketoconazole therapy for blastomycosis and following its completion is recommended.
C A Hebert; J W King; R B George
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  95     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-01     Completed Date:  1989-02-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  240-2     Citation Subset:  AIM; IM    
Department of Medicine, Louisiana State University School of Medicine, Shreveport.
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MeSH Terms
Blastomycosis / drug therapy*,  pathology,  radiography
Dermatomycoses / pathology
Ketoconazole / therapeutic use*
Lung / radiography
Lung Diseases, Fungal / drug therapy*,  radiography
Skin / pathology
Reg. No./Substance:

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