Document Detail

Late crust formation as a predictor of healing of traumatic, dry, and minor-sized tympanic membrane perforations.
MedLine Citation:
PMID:  23313119     Owner:  NLM     Status:  Publisher    
OBJECTIVE: The goal of this study was to evaluate the effects of crust formation on the healing of traumatic, dry, and minor-sized tympanic membrane perforations (TMPs) in humans. STUDY DESIGN: Case series with a chart review. SETTING: Tertiary university hospital. MATERIALS AND METHODS: The clinical records of patients with traumatic TMPs who met the case selection criteria were retrieved and categorized according to the presence of a crust and the timing of crust formation into three groups: no crust, early crust formation, and late crust formation. Healing outcomes (i.e., healing rate and time) in the three groups were analyzed. RESULTS: In total, 83 patients were analyzed. The perforation closure rates were 92%, 100%, and 78% in the groups with no-crust, early crust formation, and late crust formation, respectively. No significant difference was seen between the groups with no-crust and with late crust formation (p>0.05). By contrast, closure rates differed significantly between the early and late crust formation groups (p<0.05). Overall, the no-crust and early crust formation groups showed shorter healing times compared with the late crust formation group (p<0.05). However, closure times did not differ significantly between groups with early crust formation and no crust (p>0.05). CONCLUSIONS: Crust formation at the margin of a traumatic TMP may serve as a predictor of healing outcome. Compared with perforations with early crust formation or no crust, late crust formation can result in delayed healing and failure to close completely.
Zhengcai Lou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  American journal of otolaryngology     Volume:  -     ISSN:  1532-818X     ISO Abbreviation:  Am J Otolaryngol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Otorhinolaryngology, The Affiliated YiWu Hospital of Wenzhou Medical College, Zhejiang, China. Electronic address:
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