Document Detail

Late circulatory dysfunction and decreased cerebral blood flow volume in infants with periventricular leukomalacia.
MedLine Citation:
PMID:  18367356     Owner:  NLM     Status:  MEDLINE    
Periventricular leukomalacia is a major neuropathology in preterm infants associated with adverse motor and cognitive outcome. The cerebral blood flow volume of the internal carotid artery and the vertebral artery was measured by ultrasonography at the neck in 36 low-birth-weight infants with gestational age of 25-34 weeks in order to investigate the pathophysiology of cerebral white-matter injury: 30 infants, normal and 6 infants, diagnosed as PVL. The mean blood flow velocity and diameter of each vessel were measured at postnatal days from day 0 to day 70. The intravascular flow volume was determined by calculating the mean blood flow velocity and the cross-sectional area. The mean blood pressures were recorded and PaCO(2) was determined. The total blood flow volume was significantly lower in infants with PVL than in normal infants on days 0, 1, 21, 28, 35, 42, and 63. The mean blood pressure was significantly lower in infants with PVL than in normal infants on days 7, 14, 21, 28, and 42. We suggest that the total cerebral blood supply is decreased in cases of PVL in the few days after birth and from day 21 to day 42. The results of the present study suggest that a dip in the blood flow volume in the few days after birth might result in subsequent PVL.
Sumio Fukuda; Keisuke Mizuno; Hiroki Kakita; Takenori Kato; Mohamed Hamed Hussein; Tetsuya Ito; Ghada A Daoud; Ineko Kato; Satoshi Suzuki; Hajime Togari
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Publication Detail:
Type:  Journal Article     Date:  2008-03-25
Journal Detail:
Title:  Brain & development     Volume:  30     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2008-10-15     Revised Date:  2009-05-08    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  589-94     Citation Subset:  IM    
Nagoya City University, Graduate School of Medical Sciences, Department of Pediatrics, Neonatology and Congenital Disorders, Kawasumi, Mizuho, Nagoya, Aichi 467-8601, Japan.
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MeSH Terms
Blood Flow Velocity*
Blood Pressure
Cerebrovascular Circulation / physiology*
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases* / pathology,  ultrasonography
Leukomalacia, Periventricular* / pathology,  ultrasonography
Comment In:
Brain Dev. 2009 Jun;31(6):473   [PMID:  19179028 ]

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