Document Detail

Late cardiovascular complications after surgical or balloon angioplasty of coarctation of aorta in an Asian cohort.
MedLine Citation:
PMID:  19801038     Owner:  NLM     Status:  MEDLINE    
Late cardiovascular complications after intervention for coarctation of the aorta (CoA) might be common. Such data, especially in Asian populations, are still limited. A total of 169 patients with CoA who survived balloon (n = 41) or surgical (n = 128) intervention from 1986 to 2004 were enrolled. The total follow-up was 1,776 patient-years, and the patient age at last follow-up was 14.7 +/- 8.5 years. Reintervention for recoarctation, systemic hypertension, and left ventricular outflow tract obstruction (LVOTO) was subsequently noted in 57 (34%), 36 (21.3%), and 24 (14.2%) patients, respectively, without significant differences between the balloon and surgical groups. The 20-year freedom from reintervention, systemic hypertension, and LVOTO rate was 52%, 78.6%, and 80.8% in the balloon group and 59%, 51%, and 81.9% in the surgical group, respectively. The age at CoA intervention and the aortic geometry after CoA intervention of gothic type were common risk factors for reintervention for recoarctation and late systemic hypertension. In contrast, the presence of bicuspid aortic valves and gothic arch geometry after CoA intervention increased the risk of LVOTO. Plasma renin/aldosterone activities were not elevated in those with or without systemic hypertension. In conclusion, the profile of reintervention for recoarctation and late systemic hypertension after CoA interventions in our Asian cohort with CoA was similar to that observed in white patients. Asian patients might have a lower risk of LVOTO.
Hsin-Hui Chiu; Shuenn-Nan Chiu; Fu-Chang Hu; Chun-An Chen; Ming-Tai Lin; Jou-Kou Wang; Chung-I Chang; Yih-Shang Chen; Ing-Sh Chiu; Mei-Hwan Wu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  104     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1139-44     Citation Subset:  AIM; IM    
Department of Pediatrics, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, Taiwan.
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MeSH Terms
Angioplasty, Balloon / adverse effects*
Aortic Coarctation / diagnosis,  therapy*
Asian Continental Ancestry Group*
Blood Pressure
Cardiac Surgical Procedures / adverse effects*
Child, Preschool
Diagnosis, Differential
Echocardiography, Doppler
Follow-Up Studies
Hypertension / diagnosis,  ethnology*,  etiology
Middle Aged
Retrospective Studies
Risk Factors
Severity of Illness Index
Taiwan / epidemiology
Time Factors
Tomography, X-Ray Computed
Ventricular Outflow Obstruction / diagnosis,  ethnology*,  etiology
Young Adult

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