Document Detail

Late cardiotoxicity of anthracyclines in children with acute leukemia.
MedLine Citation:
PMID:  10472576     Owner:  NLM     Status:  MEDLINE    
Congestive heart failure is one the most severe late complications of cancer therapy with anthracyclines. The function of the heart muscle was evaluated in 50 children (30 boys and 20 girls), aged from 5 years 6 months to 20 years 7 months, treated in the past for lymphoblastic or nonlymphoblastic acute leukemia. The total dose of the administrated anthracyclines was 120-550 mg/m2. The circulatory system was evaluated on the basis of history, physical examination, ECG, exercise test and echocardiography. Impaired contractility of the heart muscle was found in 32% of cases. The degree of impairment was related to the total dose of anthracyclines and to the period from discontinuation of therapy. Heart muscle function disorders were present also in children, in whom the cumulative dose of anthracycline antibiotics did not exceed 400 mg/m2. In the majority of patients the evidence of heart damage was subclinical.
B Zalewska-Szewczyk; J Lipiec; J Bodalski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Klinische Pädiatrie     Volume:  211     ISSN:  0300-8630     ISO Abbreviation:  Klin Padiatr     Publication Date:    1999 Jul-Aug
Date Detail:
Created Date:  1999-10-22     Completed Date:  1999-10-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  356-9     Citation Subset:  IM    
II Clinic of Children's Diseases, Institute of Pediatrics, Medical University of Lódz.
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MeSH Terms
Antibiotics, Antineoplastic / adverse effects*
Child, Preschool
Dose-Response Relationship, Drug
Follow-Up Studies
Heart Failure / chemically induced*,  diagnosis*,  physiopathology
Leukemia, Myeloid, Acute / drug therapy*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Reg. No./Substance:
0/Antibiotics, Antineoplastic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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