Document Detail

Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil.
MedLine Citation:
PMID:  1891213     Owner:  NLM     Status:  MEDLINE    
The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy. Mean follow-up was 23.7 +/- 16.3 months (range, 3 to 60 months). Thirteen eyes (5.7%) of 11 patients developed bleb-related endophthalmitis an average of 25.9 +/- 17.4 months (range, 5 to 58 months) after surgery. Infection occurred in 9 of 96 (9.4%) procedures performed from below and in 4 of 133 (3.0%) procedures performed superiorly (P = 0.05, Fisher's exact test). The relative risk of bleb-related endophthalmitis in trabeculectomy from below versus above is 4.0 after adjustment for age and sex (95% confidence interval = 1.1, 14.8). Trabeculectomy with adjunctive 5-FU performed from below carries an increased risk of late bleb-related infection. The incidence of late bleb-related endophthalmitis after 5-FU trabeculectomy appears to be higher than that for trabeculectomy without adjunctive 5-FU injections.
B Wolner; J M Liebmann; J W Sassani; R Ritch; M Speaker; M Marmor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ophthalmology     Volume:  98     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-10-15     Completed Date:  1991-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1053-60     Citation Subset:  IM    
Department of Ophthalmology, New York Eye and Ear Infirmary, New York City 10003.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use
Child, Preschool
Endophthalmitis / drug therapy,  etiology*
Eye Infections, Bacterial / drug therapy,  etiology
Fluorouracil / therapeutic use*
Follow-Up Studies
Glaucoma / drug therapy,  surgery*
Intraocular Pressure / drug effects
Middle Aged
Retrospective Studies
Risk Factors
Trabeculectomy / adverse effects*
Visual Acuity / drug effects
Reg. No./Substance:
0/Anti-Bacterial Agents; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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