| Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. | |
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MedLine Citation:
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PMID: 1891213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy. Mean follow-up was 23.7 +/- 16.3 months (range, 3 to 60 months). Thirteen eyes (5.7%) of 11 patients developed bleb-related endophthalmitis an average of 25.9 +/- 17.4 months (range, 5 to 58 months) after surgery. Infection occurred in 9 of 96 (9.4%) procedures performed from below and in 4 of 133 (3.0%) procedures performed superiorly (P = 0.05, Fisher's exact test). The relative risk of bleb-related endophthalmitis in trabeculectomy from below versus above is 4.0 after adjustment for age and sex (95% confidence interval = 1.1, 14.8). Trabeculectomy with adjunctive 5-FU performed from below carries an increased risk of late bleb-related infection. The incidence of late bleb-related endophthalmitis after 5-FU trabeculectomy appears to be higher than that for trabeculectomy without adjunctive 5-FU injections. |
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Authors:
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B Wolner; J M Liebmann; J W Sassani; R Ritch; M Speaker; M Marmor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ophthalmology Volume: 98 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-10-15 Completed Date: 1991-10-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1053-60 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, New York Eye and Ear Infirmary, New York City 10003. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents / therapeutic use Child Child, Preschool Endophthalmitis / drug therapy, etiology* Eye Infections, Bacterial / drug therapy, etiology Female Fluorouracil / therapeutic use* Follow-Up Studies Glaucoma / drug therapy, surgery* Humans Incidence Intraocular Pressure / drug effects Male Middle Aged Retrospective Studies Risk Factors Trabeculectomy / adverse effects* Visual Acuity / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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