| Late auditory event-related evoked potential (P300) in Down's syndrome patients. | |
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MedLine Citation:
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PMID: 20549081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the latencies and amplitudes of evoked late auditory potential related to P300 events and their changes in young adults with Down's syndrome. MATERIALS AND METHODS: Prospective case study. P300 test latency and amplitudes were evaluated in 17 individuals with Down's syndrome and 34 healthy individuals. RESULTS The P300 latency (N1, P2, N2 and P3) was longer and the N2-P3 amplitude was lower in individuals with Down syndrome when compared to those in the control group. CONCLUSION: In young adults with Down syndrome, N1, P2, N2 and P3 latencies of late auditory evoked potential related to P300 events were prolonged, and N2 - P3 amplitudes were significantly reduced, suggesting integration impairment between the auditory association area and cortical and subcortical areas of the central nervous system. |
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Authors:
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Carla Patrícia Hernandez Alves Ribeiro César; Heloisa Helena Caovilla; Mário Sérgio Lei Munhoz; Maurício Malavasi Ganança |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of otorhinolaryngology Volume: 76 ISSN: 1808-8686 ISO Abbreviation: Braz J Otorhinolaryngol Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-06-15 Completed Date: 2010-10-04 Revised Date: 2011-10-04 |
Medline Journal Info:
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Nlm Unique ID: 101207337 Medline TA: Braz J Otorhinolaryngol Country: Brazil |
Other Details:
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Languages: eng Pagination: 206-12 Citation Subset: IM |
Affiliation:
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Sao Paulo Federal University, Paulista Medical School. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Down Syndrome / physiopathology* Event-Related Potentials, P300 / physiology* Evoked Potentials, Auditory / physiology* Female Humans Male Prospective Studies Reaction Time Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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