Document Detail

Late adverse effects after soft X-ray therapy of cutaneous malignancies: pruritus, burning, epiphora and insufficient occlusion of the mouth.
MedLine Citation:
PMID:  18070025     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pruritus, burning, epiphora and insufficient occlusion of the mouth have been less extensively studied than cosmetic changes in irradiated fields. OBJECTIVES: How frequent are these late adverse effects? Do they usually occur permanently? Are they influenced by treatment and tumour parameters, sex and age of the patients? METHODS: Patients were interviewed at least once later than 90 days after soft X-ray therapy. RESULTS: Pruritus has been reported in 18.5% of the interviews, burning in 7.7%, epiphora in 36.2% and insufficient occlusion of the mouth in 11.5%. Patients were usually not permanently troubled and irritated by these symptoms: pruritus more than once per week was reported in every interview for 0.6% of the fields, burning for 0.2%, epiphora for 6.4% and insufficient occlusion for 0%. Irritation by these symptoms has been stated in every interview for 5.1% of fields around the eye and for 1.4% of fields at other sites. Late pruritus, burning and epiphora were less frequently reported after irradiation with lower total doses, lower time-dose-fractionation factor (TDF) and by men. Patients older than 70 years of age experienced pruritus and burning less frequently. The largest diameter of the irradiated field influenced pruritus and the half value depth of the X-rays influenced burning and epiphora. CONCLUSIONS: Late pruritus, burning, epiphora and insufficient occlusion of the mouth do not considerably reduce the value of soft X-ray therapy because these adverse effects usually are not experienced permanently. Total dose and TDF should not be chosen higher than necessary.
K-W Schulte; C Auras; G Bramkamp; C Breitkopf; H-J Elsmann; E M Habenicht; V Jasnoch; A Lippold; A Lösler; R Rupprecht; H Müller-Pannes; L Suter
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Publication Detail:
Type:  Journal Article     Date:  2007-12-07
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  22     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-15     Completed Date:  2008-05-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  555-60     Citation Subset:  IM    
Fachklinik Hornheide, Münster, Germany.
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MeSH Terms
Dose-Response Relationship, Radiation
Follow-Up Studies
Lacrimal Apparatus Diseases / etiology
Malocclusion / etiology
Pain / etiology
Pruritus / etiology
Radiation Injuries / epidemiology,  pathology*
Retrospective Studies
Skin Neoplasms / radiotherapy*
X-Ray Therapy / adverse effects*

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