Document Detail

Late polypropylene mesh susceptibility to infection during intra-abdominal sepsis.
MedLine Citation:
PMID:  21867388     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the susceptibility of high-density polypropylene mesh to contamination, 1 year after experimental hernia repair.
METHODS: Wistar rats were randomized into two groups: one experimental group (n = 20) and another control group (n = 10). Mesh hernia repair was performed with intra-abdominal (group I, n = 10) or subcutaneous (group II, n = 10) implantation of grafts. The three groups were exposed to an intra-abdominal E. coli administration after 1 year of operation. After 24 hr, the meshes and peritoneum were sampled from the experimental and control groups, respectively, in order to assess bacterial inoculation. Immunoreaction to E. coli inoculation was also evaluated after 24 hr by measuring serum interleukin-6 (IL-6) and C-reactive protein (CRP) levels.
RESULTS: Bacteriological analysis revealed increased contamination in groups I and II when compared with the control group (p = .001 and .007, respectively). IL-6 levels were increased in both groups I and II compared with the control group, 24 hr after E. coli injection (p = .034 and .022, respectively), while there was no statistically significant difference between groups concerning the concentration of CRP.
CONCLUSIONS: Polypropylene mesh is vulnerable to bacterial inoculation during intra-abdominal sepsis 1 year after mesh placement.
Ioannis Vassiliou; Vassiliou Ioannis; Aliki Tympa; Tympa Aliki; Theodosios Theodosopoulos; Theodosopoulos Theodosios; Constantinos Nastos; Nastos Constantinos; Nikolaos Arkadopoulos; Arkadopoulos Nikolaos; Nikolaos Dafnios; Dafnios Nikolaos; Georgios Fragulidis; Fragulidis Georgios; Evangelia Kouskouni; Kouskouni Evangelia; Vassilios Smyrniotis; Smyrniotis Vassilios
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  24     ISSN:  1521-0553     ISO Abbreviation:  J Invest Surg     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-26     Completed Date:  2011-12-15     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Second Department of Surgery, Experimental Surgery Unit, School of Medicine, Aretaieion University Hospital, University of Athens, Greece.
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MeSH Terms
C-Reactive Protein / analysis
Escherichia coli Infections / etiology*
Escherichia coli O157
Hernia, Abdominal / surgery
Herniorrhaphy / adverse effects
Interleukin-6 / analysis
Postoperative Complications / microbiology
Prostheses and Implants / microbiology*
Rats, Wistar
Sepsis / complications*
Surgical Mesh / microbiology*
Reg. No./Substance:
0/Interleukin-6; 0/Polypropylenes; 9007-41-4/C-Reactive Protein
Erratum In:
J Invest Surg. 2013 Jun;26(3):165
Note: Ioannis, Vassiliou [corrected to Vassiliou, Ioannis]; Aliki, Tympa [corrected to Tympa, Aliki]; Theodosios, Theodosopoulos [corrected to Theodosopoulos, Theodosios]; Constantinos, Nastos [corrected to Nastos, Constantinos]; Nikolaos, Arkadopoulos [corrected to Arkadopoulos, Nikolaos]; Nikolaos, Dafnios [corrected to Dafnios, Nikolaos]; Georgios, Fragulidis [corrected to Fragulidis, Georgios]; Evangelia, Kouskouni [corrected to Kouskouni, Evangelia]; Vassilios, Smyrniotis [corrected to Smyrniotis, Vassilios]

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