Document Detail


Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births.
MedLine Citation:
PMID:  23324523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To describe and compare the incidence of late-onset sepsis (LOS) and demographic and clinical characteristics associated with LOS in very low birth weight (VLBW) infants from singleton and multiple births, and to examine the heritability of susceptibility to LOS among VLBW twins by comparing same-sex and unlike-sex twin pairs.
STUDY DESIGN: The study group comprised infants with birth weight 401-1500 g seen at clinical centers of the Eunice Kennedy Shriver National Institute of Child and Human Development Neonatal Research Network between 2002 and 2008. Only the first episode of LOS was included in our analysis. Stepwise logistic regression models were fitted separately for singleton and multiple pregnancies to examine the maternal and neonatal factors associated with LOS. LOS due solely to gram-negative bacteria in singleton and multiple pregnancies was also examined in separate models. The heritability of LOS was estimated by examining the concordance of LOS in twins from same-sex and unlike-sex pairs.
RESULTS: LOS occurred in 25.0% (3797 of 15,178) of singleton and 22.6% (1196 of 5294) of multiple-birth VLBW infants. Coagulase-negative staphylococci were the most common infecting organisms, accounting for 53.2% of all LOS episodes in singletons and 49.2% in multiples. Escherichia coli and Klebsiella species were the most commonly isolated gram-negative organisms, and Candida albicans was the most commonly isolated fungus. Concordance of LOS did not differ significantly between same-sex and unlike-sex twin pairs.
CONCLUSION: LOS remains a common problem in VLBW infants. The incidence of LOS is similar for singleton and multiple-birth infants. The similar concordance of LOS in same-sex and unlike-sex twin pairs provides no evidence that susceptibility to LOS among VLBW infants is genetically determined.
Authors:
Nansi S Boghossian; Grier P Page; Edward F Bell; Barbara J Stoll; Jeffrey C Murray; C Michael Cotten; Seetha Shankaran; Michele C Walsh; Abbot R Laptook; Nancy S Newman; Ellen C Hale; Scott A McDonald; Abhik Das; Rosemary D Higgins;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-13
Journal Detail:
Title:  The Journal of pediatrics     Volume:  162     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-27     Completed Date:  2013-08-06     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1120-4, 1124.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Incidence
Infant, Newborn
Infant, Premature, Diseases / epidemiology*,  microbiology
Infant, Very Low Birth Weight
Logistic Models
Male
Multiple Birth Offspring
Risk Factors
Sepsis / epidemiology*,  microbiology
Grant Support
ID/Acronym/Agency:
M01 RR000059/RR/NCRR NIH HHS; M01 RR16587/RR/NCRR NIH HHS; M01 RR30/RR/NCRR NIH HHS; M01 RR32/RR/NCRR NIH HHS; M01 RR39/RR/NCRR NIH HHS; M01 RR44/RR/NCRR NIH HHS; M01 RR54/RR/NCRR NIH HHS; M01 RR59/RR/NCRR NIH HHS; M01 RR6022/RR/NCRR NIH HHS; M01 RR633/RR/NCRR NIH HHS; M01 RR64/RR/NCRR NIH HHS; M01 RR70/RR/NCRR NIH HHS; M01 RR7122/RR/NCRR NIH HHS; M01 RR750/RR/NCRR NIH HHS; M01 RR80/RR/NCRR NIH HHS; M01 RR8084/RR/NCRR NIH HHS; M01 RR997/RR/NCRR NIH HHS; MO1 RR125/RR/NCRR NIH HHS; U10 HD021364/HD/NICHD NIH HHS; U10 HD053109/HD/NICHD NIH HHS; U10 HD21364/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD21397/HD/NICHD NIH HHS; U10 HD27851/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27856/HD/NICHD NIH HHS; U10 HD27871/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD34216/HD/NICHD NIH HHS; U10 HD36790/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS; U10 HD40492/HD/NICHD NIH HHS; U10 HD40498/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; U10 HD40689/HD/NICHD NIH HHS; U10 HD53089/HD/NICHD NIH HHS; U10 HD53109/HD/NICHD NIH HHS; U10 HD53119/HD/NICHD NIH HHS; U10 HD53124/HD/NICHD NIH HHS; UL1 RR24139/RR/NCRR NIH HHS; UL1 RR24160/RR/NCRR NIH HHS; UL1 RR25764/RR/NCRR NIH HHS; UL1 TR000041/TR/NCATS NIH HHS
Investigator
Investigator/Affiliation:
Barbara J Stoll / ; Avroy A Fanaroff / ; Edward F Bell / ; Shahnaz Duara / ; Ronald N Goldberg / ; Abbot R Laptook / ; William Oh / ; Seetha Shankaran / ; Michele C Walsh / ; Abhik Das / ; W Kenneth Poole / ; Linda L Wright / ; Rosemary D Higgins / ; Nancy S Newman / ; Ellen C Hale / ; Alan H Jobe / ; Michael S Caplan / ; Angelita M Hensman / ; Avroy A Fanaroff / ; Kurt Schibler / ; Edward F Donovan / ; Kate Bridges / ; Barbara Alexander / ; Cathy Grisby / ; Marcia Worley Mersmann / ; Holly L Mincey / ; Jody Hessling / ; Kathy J Auten / ; Kimberley A Fisher / ; Katherine A Foy / ; Sandra Grimes / ; Melody B Lohmeyer / ; David P Carlton / ; Ann M Blackwelder / ; Linda L Wright / ; Stephanie Wilson Archer / ; Brenda B Poindexter / ; James A Lemons / ; Dianne E Herron / ; Lucy C Miller / ; Leslie Dawn Wilson / ; Betty K Hastings / ; Jeanette O'Donnell Auman / ; Carolyn Petrie Huitema / ; Kristin Zaterka-Baxter / ; Krisa P Van Meurs / ; David K Stevenson / ; Marian M Adams / ; M Bethany Ball / ; Melinda S Proud / ; Andrew W Palmquist / ; Ivan D Frantz / ; Brenda L MacKinnon / ; Ellen Nylen / ; Waldemar A Carlo / ; Namasivayam Ambalavanan / ; Monica V Collins / ; Shirley S Cosby / ; Neil N Finer / ; Paul R Wozniak / ; Maynard R Rasmussen / ; Kathy Arnell / ; Clarence Demetrio / ; Chris Henderson / ; Wade Rich / ; John A Widness / ; Karen J Johnson / ; Nancy J Krutzfield / ; Shahnaz Duara / ; Ruth Everett-Thomas / ; Kristi L Watterberg / ; Lu-Ann Papile / ; Conra Backstrom Lacy / ; Dale L Phelps / ; Linda J Reubens / ; Mary Rowan / ; Erica Burnell / ; Pablo J Sánchez / ; Charles R Rosenfeld / ; Walid A Salhab / ; Gaynelle Hensley / ; Melissa H Leps / ; Nancy A Miller / ; Alicia Guzman / ; Susie Madison / ; Kathleen A Kennedy / ; Jon E Tyson / ; Esther G Akpa / ; Patty A Cluff / ; Beverly Foley Harris / ; Claudia I Franco / ; Anna E Lis / ; Sarah Martin / ; Georgia E McDavid / ; Maegan C Simmons / ; Patti Pierce Tate / ; Roger G Faix / ; Bradley A Yoder / ; Karen A Osborne / ; Jill Burnett / ; Jennifer J Jensen / ; Cynthia Spencer / ; Kimberlee Weaver-Lewis / ; T Michael O'Shea / ; Nancy J Peters / ; Rebecca Bara / ; Geraldine Muran / ; Richard A Ehrenkranz / ; Harris C Jacobs / ; Patricia Cervone / ; Patricia Gettner / ; Monica Konstantino / ; JoAnn Poulsen / ; Janet Taft /

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