Document Detail

Late-life depression as a risk factor for mild cognitive impairment or Alzheimer's disease in 30 US Alzheimer's disease centers.
MedLine Citation:
PMID:  22543846     Owner:  NLM     Status:  MEDLINE    
Identification of potentially modifiable risk factors for cognitive deterioration is important. We conducted a prospective study of 5,607 subjects with normal cognition and 2,500 subjects with mild cognitive impairment (MCI) at 30 Alzheimer's Disease Centers in the Unites States between 2005 and 2011. Cox regression was used to determine whether depression predicted transition from normal to MCI, or MCI to Alzheimer's disease (AD). Over an average of 3.3 visits, 15% of normal subjects transitioned to MCI (62/1000 per year), while 38% of MCI subjects transitioned to AD (146/1000 per year). At baseline, 22% of participants had recent (within the last two years) depression defined by clinician judgment; 9% and 17% were depressed using the Geriatric Depression Scale (GDS score ≥5) and the Neuropsychiatric Inventory Questionnaire (NPI-Q), respectively. At baseline, depressed subjects performed significantly worse on cognitive tests. Those always depressed throughout follow-up had an increased risk for progression from normal to MCI (RR = 2.35; 95% CI 1.93-3.08) versus never depressed. Normal subjects, identified as depressed at first visit but subsequently improved, were found to have lower risk of progression (RR 1.40 (1.01-1.95)). The 'always depressed' had only a modest increased risk of progression from MCI to AD (RR = 1.21 (1.00-1.46). Results were similar using time-dependent variables for depression or when defining depression via the GDS or NPI-Q. We found no effect of earlier depression (>2 years past). The effect of recent depression did not differ by antidepressant treatment, APOE4 allele status, or type of MCI. In conclusion, late-life depression is a strong risk factor for normal subjects progressing to MCI.
Kyle Steenland; Conny Karnes; Ryan Seals; Claudine Carnevale; Adriana Hermida; Allan Levey
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  31     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-01     Completed Date:  2013-06-04     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  265-75     Citation Subset:  IM    
Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
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MeSH Terms
Age Factors
Aged, 80 and over
Alzheimer Disease / diagnosis,  epidemiology*,  psychology*
Cohort Studies
Depression / diagnosis,  epidemiology*,  psychology*
Follow-Up Studies
Information Centers
Middle Aged
Mild Cognitive Impairment / diagnosis,  epidemiology*,  psychology*
Prospective Studies
Risk Factors
United States / epidemiology
Grant Support
P50 AG025688/AG/NIA NIH HHS; U01 AG016976/AG/NIA NIH HHS; U01 AG016976/AG/NIA NIH HHS

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