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Latanoprost versus timolol as first choice therapy in patients with ocular hypertension.
MedLine Citation:
PMID:  20731623     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Purpose:  To determine the cost-effectiveness of ocular hypertension (OH) treatment initiated with latanoprost compared to timolol. Methods:  Two strategies for OH therapy are modelled, (1) 'starting with timolol' and (2) 'starting with latanoprost'. Therapy can be maintained or changed dependent on the achieved intraocular pressure (IOP) and side-effects. Adjustments of therapy to reach a target pressure involve monotherapy, combination therapy and laser. Four drugs are used: latanoprost, timolol, brimonidine and dorzolamide. Once the adjustments of therapy are completed, lifelong follow-up with IOP-dependent conversion to glaucoma and progression to blindness are modelled. Direct medical costs are assigned. The IOP-lowering effect of drugs is based on meta-analyses and applied by Monte Carlo simulation to a hypothetical cohort of patients with OH. The characteristics of the cohort, including the initial IOP distribution, are based on data of 1000 patients. Results:  The IOP decreased from 25,4 mm Hg (mean) to 16.7 (±0.017) mm Hg (strategy 1) and to 16.5 (±0.013) mm Hg (strategy 2). Costs per patient within 15 months of therapy were € 367 and € 469, respectively. Lifetime blindness and costs were 0.0334 years and € 3 514 (strategy 1) and 0.0318 years and € 4 397 (strategy 2). Incremental costs per year of vision saved for strategy (2) in comparison with strategy (1) amount to, given the uncertainties in the model, approximately € 537 000. Conclusion:  For saving 1 year of vision, high costs are needed when OH therapy is initiated with latanoprost compared to timolol, when the cost price of latanoprost remains high.
Authors:
Andrea Peeters; Jan S A G Schouten; Johan L Severens; Fred Hendrikse; Martin H Prins; Carroll A B Webers
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Publication Detail:
Type:  Journal Article     Date:  2010-08-20
Journal Detail:
Title:  Acta ophthalmologica     Volume:  90     ISSN:  1755-3768     ISO Abbreviation:  Acta Ophthalmol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468102     Medline TA:  Acta Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  146-54     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Acta Ophthalmologica © 2010 Acta Ophthalmologica Scandinavica Foundation.
Affiliation:
Department of Ophthalmology, Maastricht University Medical Centre, Maastricht, The Netherlands Department of Epidemiology, Maastricht University, Maastricht, The Netherlands Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, The Netherlands Department of Health Organisation, Policy and Economics, Maastricht University, The Netherlands.
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