| Latanoprost exposure in pregnancy. | |
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MedLine Citation:
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PMID: 15289149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To observe pregnancies exposed to latanoprost, a prostaglandin analog administered in the treatment of glaucoma. Its prescription is limited in pregnancy, because reproduction studies in animals report a high incidence of abortion and human investigations are not adequate. As a consequence it is classified as category C drug according to the United States Food and Drug Administration's use-in-pregnancy ratings. DESIGN: Observational study. METHODS: We collected data, referred to our Teratology Information Service, relative to latanoprost exposure in pregnancy. We followed by phone interviews women treated with latanoprost during the first trimester, and we evaluated whether there had been any adverse effects on the fetus. RESULTS: Eleven cases of latanoprost exposure in pregnancy were referred to our Teratology Information Service. One case was lost to follow-up, and one case was complicated by miscarriage. Nine cases had a complete follow-up without congenital anomalies. CONCLUSIONS: Our series is too small to perform statistical significance; however, we found no evidence of adverse effects of latanoprost on pregnancy or neonatal outcomes. |
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Authors:
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Marco De Santis; Angela Lucchese; Brigida Carducci; Anna F Cavaliere; Lidia De Santis; Annamaria Merola; Gianluca Straface; Alessandro Caruso |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of ophthalmology Volume: 138 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-03 Completed Date: 2004-08-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 305-6 Citation Subset: AIM; IM |
Affiliation:
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Telefono Rosso Teratology Information Service, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy. marcodesantis@rm.unicatt.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology Adult Antihypertensive Agents / adverse effects, therapeutic use* Embryonic and Fetal Development / drug effects Female Glaucoma, Open-Angle / drug therapy* Humans Intraocular Pressure / drug effects Middle Aged Ocular Hypertension / drug therapy Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Prostaglandins F, Synthetic / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Prostaglandins F, Synthetic; 130209-82-4/latanoprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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