Document Detail

Laserspectroscopy in the fetus during labour.
MedLine Citation:
PMID:  12965101     Owner:  NLM     Status:  MEDLINE    
The newly available modified laserspectroscopy for fetal physiologic measurements provides information about biochemical parameters and is potentially an additional technique for fetal surveillance. METHOD: Using laserspectroscopy it was possible to trace changes in absorbances at four different wavelengths and to calculate relative changes of HbO2, desaturated haemoglobin, total haemoglobin, and cytochrome aa3. Using an experimental set-up with fetal lamb during intermittend cord occlusion, we were able to study tissue oxygenation of the fetal brain (tpO2) under defined conditions. Furthermore, the NIR sensor was used during physiologic measurements in the human fetus. RESULTS: As had been proposed earlier, it is obvious that the tolerance to hypoxia is increased after cord compression is repeated, as is indicated by the shifting of the cytochrome dissociation curve to the left. In the human fetus without fetal distress we observed stable values with only minor fluctuations related to changes of intrauterine pressure. On the other hand, in cases where there was an intrauterine complication the deterioration of oxygenation was detected form a decrease in HbO2 and cytochrome aa3. DISCUSSION AND CONCLUSION: The routinely used CTG has been criticised for the effect of leading to an unacceptably high number of cesarean sections. Information on biochemical variables leads to better identification of fetal distress. In comparison to fetal blood sampling NIR laserspectroscopy holds the promise of a non-invasive tool providing continues monitoring.
Stephan Schmidt
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  110 Suppl 1     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-10     Completed Date:  2004-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S127-31     Citation Subset:  IM    
Phillipps-Universitat Marburg, Biegenstrabe 10, Marburg 35032, Germany.
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MeSH Terms
Electron Transport Complex IV / analysis,  blood
Fetal Blood / chemistry
Fetal Hypoxia / diagnosis*
Hemoglobins / analysis
Labor, Obstetric*
Spectroscopy, Near-Infrared*
Reg. No./Substance:
0/Hemoglobins; EC Transport Complex IV

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