| Laser speckle contrast imaging accurately measures blood flow over moving skin surfaces. | |
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MedLine Citation:
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PMID: 21156183 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cutaneous blood flow (CBF) can be assessed non-invasively with lasers. Unfortunately, movement artefacts in the laser skin signal (LS(sk)) might sometimes compromise the interpretation of the data. To date, no method is available to remove movement artefacts point-by-point. Using a laser speckle contrast imager, we simultaneously recorded LS(sk) and the signal backscattered from an adjacent opaque surface (LS(os)). The completion of a first protocol allowed a definition of a simple equation to calculate the CBF from movement artefact-affected traces of LS(sk) and LS(os). We then recorded LS(sk) and LS(os) before, during and for 5min after the tourniquet ischemia, both when subjects (n=8) were immobile or submitted to external passive movements of random intensity throughout the test. The typical post-occlusive reactive hyperemia trace was not identifiable within the LS(sk) recordings, with LS(sk) being 2 to 3 times higher during movements than in the immobile situation. After the calculation of CBF, traces in the immobile versus movement conditions were comparable, with the "r" cross-correlation coefficient being 0.930+/-0.010. Our method might facilitate future investigations in microvascular physiology and pathophysiology, specifically in subjects who have frequent or continuous involuntary movements. |
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Authors:
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Guillaume Mahé; Pascal Rousseau; Sylvain Durand; Stephanie Bricq; Georges Leftheriotis; Pierre Abraham |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-13 |
Journal Detail:
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Title: Microvascular research Volume: - ISSN: 1095-9319 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Vascular Investigations, University Hospital of Angers, France; Biologie Neurovasculaire Intégrée (BNVI), Unité mixte UMR CNRS 6214/INSERM 771, Faculté de Médecine, Angers, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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