| Laser photoablation of experimental post-infarction ventricular tachycardia guided by three dimensional activation mapping. | |
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MedLine Citation:
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PMID: 9047165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: The purpose of this study was to evaluate the efficacy of epicardially delivered laser energy to ablate induced ventricular tachycardia in a post-infarction canine model. STUDY DESIGN/MATERIALS AND METHODS: In 13 canines, the left anterior wall myocardial infarction was created. Five days later, 240 plunged electrodes were inserted into the heart. Three-dimensional ventricular activation sequences were analyzed on line by a computerized mapping system. RESULTS: Sixteen sustained monomorphic ventricular tachycardias were reproducibly induced in 10 canines. Epicardially contacted Nd:YAG laser irradiated the areas of the final pathway in macro-reentrant activation and the impulse origin in focal excitation. Linear photocoagulation lesions (11-16 x 50-72 mm) were created. Seven macro-reentrant circuits and six of nine focal origins were eliminated (success rate 81%). Pathology showed that laser photocoagulation involved all surviving subepicardial and intramural fibers. CONCLUSION: Epicardially delivered laser energy in conjunction with electrical activation mapping has a high probability of ablating post-infarction ventricular tachycardia. |
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Authors:
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G Wu; R H Svenson; L Littmann; C H Chuang; M Thompson; G A Nanney; R Splinter; G P Tatsis; K R Dezern |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 20 ISSN: 0196-8092 ISO Abbreviation: Lasers Surg Med Publication Date: 1997 |
Date Detail:
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Created Date: 1997-06-13 Completed Date: 1997-06-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 119-30 Citation Subset: IM |
Affiliation:
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Laser and Applied Technologies Laboratory, Carolinas Medical Center, Charlotte, North Carolina 28232, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Electric Conductivity Electrocardiography Female Heart Septum / pathology Laser Coagulation* Male Myocardial Infarction / complications* Tachycardia, Ventricular / pathology, surgery* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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