Document Detail

Laser-induced withdrawal test for electrophysiological recordings of nociception.
MedLine Citation:
PMID:  21983743     Owner:  NLM     Status:  Publisher    
CO(2) lasers are often used in pain research. However, the stimulation parameters of the CO(2) lasers, such as beam diameter, laser power, etc., used for these animal nociceptive studies vary across laboratories. The differences of the parameters usually make novices who want to reproduce the laser-evoked responses confused to follow. In this study, we quantitatively measured the laser-withdrawal reflex of the rat to ascertain the individual laser-withdrawal threshold and then found the thresholds were diverse among the rats we adopted. Furthermore, the optimal stimulation distance, the most conveniently modified stimulation parameter of CO(2) laser stimuli, was also determined. We suggest that laser-withdrawal tests should be applied before the electrophysiological recordings in order to verify the efficiency of the induced nociception and substantiate the operational parameters of the CO(2) laser device.
Yu-Chieh Kao; Fu-Shan Jaw
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-8
Journal Detail:
Title:  Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology     Volume:  -     ISSN:  1432-1351     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101141792     Medline TA:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
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